摘要
目的研究房颤患者vWF、ADAMTS-13的变化及意义。方法分别测定27例持续性房颤、20例阵发性房颤患者和25例正常对照组血浆血管性血友病因子(vWF)、血管性血友病因子裂解酶(ADAMTS-13)水平、D-二聚体(D-D)水平,测vWF/ADAMTS-13比值。结果与对照组比较,阵发性房颤组、持续性房颤组的vWF、D-D均显著增高、ADAMTS-13明显下降,vWF/ADAMTS-13比值明显增高;vWF/ADAMTS-13比值在阵发性房颤组和持续性房颤组间差异有统计学意义,且持续性房颤组比值与D-D水平呈正相关。结论房颤患者存在有明显vWF、ADAMTS-13水平变化,且与其可能出现的血栓栓塞并发症有密切关系。
Objective To study the changes of plasma yon Willebrand factor and ADAMTSI3 in patients with atrial fibrillation and its significance. Methods The plasma VWF and ADAMTSI3 antigen levels and D-dimer levels in 20 paroxysmal AF （PAF） patients, 27 chronic AF（CAF） patients, and 25 control subjects were measured. Results Compared with the control subjects, the plasma levels of VWF and ADAMTSI3 antigen and D-D level were significantly higher（P 〈 O. 05） in patients with PAF and CAF group, vWF/ADAMTS-13 was positively correlated with D-dimer（r =0. 320, P 〈0. 05）. Conclusion Patients with atrial fibrillation show high levels of VWF and ADAMTS13 antigen and D-dimer level, which may be correlated with the embolism complication.
出处
《临床医学》
CAS
2013年第10期10-11,共2页
Clinical Medicine
