摘要
目的：了解深圳市2003～2010年出生缺陷率变化趋势及严重缺陷儿的围产期发生率逐年消长情况。方法：利用2003～2010年深圳市出生缺陷监测资料计算历年出生缺陷围产期总发生率、前5位出生缺陷以及严重缺陷儿的逐年围产期发生率。结果：深圳市2003～2010年共监测979948例围产儿，其中15767例出生缺陷儿，出生缺陷围产期平均发生率为16．09％e，呈缓慢上升趋势，胎儿水肿综合征、脑积水、肢体短缺畸形、神经管畸形、总唇裂等缺陷的围产儿发生率呈下降趋势。结论：深圳市总围产期缺陷率呈上升趋势，但严重缺陷的围产期发生率呈下降趋势。综合性预防出生缺陷措施，特别是产前筛查、产前诊断和选择性终止妊娠可有效减少严重缺陷儿的出生。
Objective： To understand the changing trend of birth defects in Shenzhen during 2003 -2010 and the fluctuation about perinatal incidence rates of severe birth defects. Methods： Annual perinatal incidence rates of total birth defects and severe birth defects were calculated by using the data of birth defect monitoring during 2003 - 2010 in Shenzhen. And the first five orders of birth defects were lis- ted during 2003 -2010. Results： There were 979 948 births who were monitored during 2003 -2010 in Shenzhen, in which 15 767 were birth defects. Perinatal incidence rate of birth defects was 16. 09 per 1 000 births with statistical - significantly growing trend. Birth defects, such as hydrops fetalis sequence, hydrocephaly, limb reduction defects, NTDs, total cleft lip , showed a decreasing trend. Conclusion： The perinatal incidence rate of total birth defects in Shenzhen shows an upward trend, while the incidence rate of severe birth defects shows a downward trend. Comprehensive measures of preventing birth defects could reduce the birth rate of severe defects, especially the prenatal screening, prenatal diagnosis and selective termination of pregnancy.
出处
《中国妇幼保健》
CAS
北大核心
2013年第36期5931-5933,共3页
Maternal and Child Health Care of China
关键词
出生缺陷
围产期
变化趋势
Birth defect
Perinatal
Changing trend
