摘要
目的 评价国产美罗培南的治疗效果与安全性。方法 采用多中心随机对照分层随机分组方法 ,以进口亚胺培南 /西司他丁为对照物 ,观察两种药物对 12 5例中 ,重度下呼吸道、泌尿系、烧伤创口感染等的疗效与安全性。结果 实验药对上述疾病总有效率为 89.36 % ,细菌清除率为 82 .2 6 % ,对照药物分别为 89.83%与 75 .0 0 % ,副作用发生率分别为 7.4%与 11.86 %。
OBJECTIVE To evaluate the efficacy and safety of domestic meropenem. METHODS A randomized comparative multicenter study was conducted to compare the efficacy and safety of domestic meropenem versus imipenem/cilastatin in the treatment of 125 cases of moderate and severe lower respiratory tract infection, urinary tract infection and infection on the surface of wound of burn. RESULTS The clinical effective and bacteriological eradication rates were 89.36% and 82.26%, respectively in meropenem group and those of the control one were 89.83% and 75.00%, respectively. Adverse events were reported in 7.4% of patients in meropenem group and 11.86% in the control one, respectively. CONCLUSIONS There were no significant differences of efficacy and adverse effect between the two groups.
出处
《中华医院感染学杂志》
CAS
CSCD
2000年第6期413-414,共2页
Chinese Journal of Nosocomiology
关键词
美罗培南
亚胺培南
细菌感染
安全性
疗效
Meropenem
Imipenem/cilastatin
Bacterial infections
Randomized comparative method
