摘要
目的:观察针刺治疗腹泻型肠易激综合征肝郁脾虚证患者的临床疗效及其对细胞因子的影响。方法:纳入40例患者,随机分为两组。针刺组21例,予针刺治疗,穴取天枢、足三里、上巨虚等,每日1次;药物组19例,予口服得舒特及双岐杆菌乳杆菌三联活菌胶囊治疗。分别在治疗1周、2周、4周后比较两组治疗前后症状评分、血清Th1型细胞因子[γ型干扰素(IFN-γ)、白介素2(IL-2)]和Th2型细胞因子(IL-4、IL-10)含量以及IFN-γ/IL-4的比值等。结果:针刺组治疗1周后临床症状即有改善(P<0.05),较药物组临床起效快(P<0.05);针刺组总有效率为90.48%(19/21),优于药物组的78.95%(15/19,P<0.05);与药物相比较,患者Th1/Th2失衡状态经针刺后明显向Th2方向转化,有恢复平衡趋势。结论:针刺对D-IBS的临床疗效与其能有效促进D-IBS肝郁脾虚证患者Th1/Th2平衡密切相关。
Objective To observe clinical therapeutic effects of acupuncture for pattern of liver-stagnation and spleen- deficiency in diarrhea-predominant irritable bowel syndrome （D-IBS） and its impact on cell factors. Methods Forty cases were selected and divided into an acupuncture group （21 cases） in which acupuncture was applied and a medicine group （19 cases） in which oral administration of dicetel and bifidobacterium lactobacitlus triple viable capsules were applied. The symptom scores, level of Thl-type cytokine （IFN-γ,IL-2） and Th2-type cytokine （IL-4、IL-10） and ratio of IFN-γ to IL- 4 were compared in two groups before and after treatment to analyze acupuncture effect. Results The clinical symptoms were improved after one-week treatment in the acupuncture group （P〈0.05）, which had faster onset than the medicine group （P〈0. 05）. The total effective rate was 90.48%（19/21） in the acupuncture group, which was superior to 78.95% （15/19） in the medicine group （P〈0.05）. Compared with medicine treatment, imbalanced condition of Thl/ Th2 was turning towards the direction of Th2 after acupuncture, indicating a tendency to recover the balance. Conclusion The clinical efficacy of acupuncture for D-IBS has close relationship with effectively improving balance of Thl/Th2 in patients with liver-stagnation and spleen-deficiency.
出处
《中国针灸》
CAS
CSCD
北大核心
2013年第12期1057-1060,共4页
Chinese Acupuncture & Moxibustion
基金
江苏省中医药管理局领军人才项目:LJ 200905
江苏省六大高峰人才项目:2009039
关键词
肠易激综合征
腹泻型
肝郁脾虚
针刺疗法
Thi
TH2
irritable bowel syndrome, diarrhea-predominan
liver-stagnation and spleen-deficiency
acupuncturetherapy
T-helper 1/T-helper 2
