摘要
目的探讨萎缩性胃炎患者血清同型半胱氨酸(Hcy)、叶酸及维生素B12水平。方法对经胃镜检查及病理确诊的萎缩性胃炎患者(萎缩性胃炎组,46例)和正常人(对照组,86例)检测血清Hcy、叶酸及维生素B12水平,分析其与萎缩性胃炎的关系。结果萎缩性胃炎组血清Hcy水平高于对照组[(18.94±10.06)μmol/L vs.(15.30±7.78)μmol/L](P<0.05)。两组血清叶酸和维生素B12水平无统计学差异[(14.89±8.56)μg/L vs.(16.46±7.35)μg/L和(518.08±274.51)ng/L vs.(521.34±266.26)ng/L](P>0.05)。幽门螺杆菌(Hp)阴性组血清Hcy水平低于Hp阳性组[(13.51±4.13)μmol/L vs.(21.84±11.11)μmol/L](P<0.01)。结论高Hcy水平是萎缩性胃炎的预测因素;Hp感染促进萎缩性胃炎的发生。
Objective To investigate serum levels of homocysteine（Hcy）, folic acid and vitamin Pn2 in patients with atrophic gastritis. Methods Serum levels of homocysteine, folic acid and vitamin 1312 were detected in 46 patients with atrophic gastritis（group A） and 86 persons without atrophic gastritis（group B）. The association of serum levels of Hcy, folic acid and vitamin B12 and atrophic gastritis was analyzed. Results Serum Hcy was higher in group A than that in group B[（18. 94± 10. 06） μmol/L vs. （15.30±7.78）μmol/L] （P〈0. 05）. Serum levels of folic acid and vitamin B12 in two groups were similar[（14. 89±8.56） μg/L vs. （16. 46±7.35）μg/L and （518.08±274. 51） ng/L vs. （521.34±266.26） ng/L]（P〈0. 05）. Serum Hcy level was lower in cases with Helicobacter pylori （Hp） negative than that in those with Hp positive [ （ 13.51 ± 4. 13）μzmol/L vs. （ 21.84±11.11 ）μmol/L]（P〈0.01）. Conclusion High level of serum Hcy is a predictor for atrophic gastritis. Hp infection promotes the occurrence of atrophic gastritis.
出处
《江苏医药》
CAS
北大核心
2013年第23期2868-2870,共3页
Jiangsu Medical Journal
基金
南京市卫生局课题(YKK11209)
