摘要
目的探讨血浆N末端B型利钠肽原(NT-proBNP)水平对射频导管消融术(RFCA)后房颤复发的影响。方法 65例阵发性房颤患者行RFCA,术后随访3个月,分为成功组(A组,54例)和复发组(B组,11例)。ELISA法检测两组治疗前和治疗后1、2和3个月血浆NT-proBNP水平。结果 B组术前血浆NT-proBNP明显高于A组[(200.7±36.3)ng/L vs.(164.5±45.4)ng/L](P<0.05),且术后NT-proBNP下降率也明显小于A组[(12.0±5.9)%vs.(23.8±5.5)%](P<0.05)。术前血浆NT-proBNP>188.1ng/L和术后NT-proBNP下降率<18.7%为RFCA术后房颤复发的独立危险因素(P<0.05);后者用于预测RFCA术后房颤复发的价值更大(P<0.05)。结论阵发性房颤患者术前血浆NT-proBNP水平升高和术后下降不明显均提示RFCA后房颤复发可能性大,后者预测价值更大。
Objective To explore the effect of level of plasma N-terminal pro-brain natriuretic peptide（NT-proBNP） on the recurrence of atrial fibrillation （AF） after radiofrequency catheter ablation（RFCA）. Methods Sixty-five patients with paroxysmal AF underwent RFCA were divided into groups of A（without recurrence of AF,54 cases） and B（with recurrence of AF, 11 cases） based on 3-month follow up after operation. Plasma NT-proBNP before and on the Ist , 2nd, and 3rd month after treatment was detected by ELISA in two groups. Results Plasma NT-proBNP before RFCA was higher in group B than that in group AF（200.7±36.3） ng/L vs. （164.5±45.4） ng/L]（P〈0. 05）. The decline rate of NT-proBNP level after RFCA was lower in group B than that in group A[（12. 0± 5.9）% vs. （23.8 ± 5.5）] （P（0. 05）. Plasma NT-proBNP was higher than 188. 1 ng/L before RFCA and its decline rate was lower than 18. 7± after RFCA were the independent risk factors for the recurrence of AF after operation （P〈0. 05）. The latter was more valuable than the formal in predicting the recurrence of AF after operation（P〈0. 05）. Conclusion AF is more likely to recur in the patients with higher level of plasma NT-proBNP before and with lower decline rate of NT-proBNP after RFCA, especially in the latter.
出处
《江苏医药》
CAS
北大核心
2013年第23期2863-2865,共3页
Jiangsu Medical Journal
关键词
N末端B型利钠肽原
心房颤动
射频导管消融术
N-terminal pro-brain natriuretic peptide~ Atrial fibrillation
Radiofrequency catheter ablation
