摘要
背景:系统性红斑狼疮是一种复杂的自身免疫性疾病,其主要病理机制与T、B淋巴细胞异常活化有关,由于系统性红斑狼疮产生多种病理性自身抗体和免疫复合物,沉积在中小血管或抗体直接侵袭血管导致管壁的炎性坏死,使血管腔变窄,促进血栓形成,导致局部组织缺血和功能障碍。间充质干细胞具有抗炎、调节系统性红斑狼疮的T、B细胞免疫紊乱、修复免疫炎性血栓形成的作用。目的:总结系统性红斑狼疮免疫性血栓形成的发病机制,介绍间充质干细胞治疗系统性红斑狼疮免疫性血栓形成的机制及临床应用前景。方法:以"systemic lupus erythematosus,mesenchymal stem cell,thrombosis,T cells,B cell,immunity"为检索词,检索Pubmed数据库、Springlink数据库、ScienceDirect数据库、HighWire数据库,检索年限为1990年1月至2013年6月,限定语种为英文;以"系统性红斑狼疮、间充质干细胞、血栓形成、T细胞、B细胞、炎症因子"为检索词,检索CNKI数据库、万方数据库、维普数据库,检索年限为1990年1月至2013年6月,限定语种为中文。共检索267篇文献,选择其中48篇文献进行分析。结果与结论:间充质干细胞具有高度自我更新能力和多向分化潜能,它通过抑制T细胞的增殖活化,改变T细胞亚群比例,抑制T细胞因子γ-干扰素、白细胞介素4分泌,从而协调系统性红斑狼疮体内的免疫平衡。间充质干细胞抑制B细胞的增殖趋化功能,抑制B细胞分泌致病性免疫球蛋白IgM、IgG、IgA,减少系统性红斑狼疮体内抗体及免疫复合物的沉积,使血管壁免遭其侵袭破坏,炎症细胞因子分泌减少,维持凝血-抗凝系统平衡,改变系统性红斑狼疮的血栓形成。
BACKGROUND： Systemic lupus erythematosus is a complex autoimmune disease of unknown origin affecting virtually every organ in the human body. It is characterized by abnormal activation of T, B lymphocytes. While aberrant T cells provide help to autoreactive B cells, the autoreactive B cells produce a variety of pathological autoantibodies and immune complex deposition, which could infiltrate the small blood vessels directly or deposit in the vessel wall, thereby causing inflammatory necrosis of the vessel walls. These changes will narrow thevascular lumen, and promote thrombosis, leading to local tissue ischemia and dysfunction. Mesenchymal stem cells can regulate the immune disorders, play an anti-inflammatory role, and repair the immune thrombosis. OBJECTIVE： To summarize the pathogenesis of immune thrombosis in systemic lupus erythematosus, as well as to introduce the mechanism of mesenchymal stem cell therapy for immunity thrombosis. METHODS＂ We searched the PubMed database, Spdnglink database, ScienceDirect database and HighWire database from January 1990 to June 2013 with the key words of systemic lupus erythematosus, mesenchymal stem cell, thrombosis, T cells, B cells＂ in English. An online search of CNKI database, Wanfang database, VIP database from January 1990 to June 2013 was also conducted with the key words of systemic lupus erythematosus, mesenchymal stem cell, thrombosis, T cells, B cells in Chinese. A total of 267 literatures were screened out, and 48 documents were included in the review based on the inclusion and exclusion criteria. RESULTS AND CONCLUSION： Mesenchymal stem cells are multipotential nonhematopoietic progenitor cells capable of multi-directional differentiating into various cell types. Mesenchymal stem cells can suppress T-lymphocyte activation and proliferation, and inhibit secretion of interferon-y, interleukin-4. Mesenchymal stem cells can also inhibit the proliferation of B cells and the secretion of pathogenic immunoglobulin IgM, IgG, IgA. Thus, mesenchymal stem ceils can regulate immune homeostasis and reduce the deposition of autoantibodies and immune complexes, thereby protecting the blood vessels from injury, reducing the secretion of inflammatory cytokines, balancing the coagulation-anticoagulation, and decreasing thrombosis in systemic lupus erythematosus.
出处
《中国组织工程研究》
CAS
CSCD
2013年第45期7968-7974,共7页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金项目(81270590)
江苏省卫生厅资助项目(H201048)~~
