摘要
目的:调查武汉地区非淋菌性尿道炎(NGU)患者泌尿生殖道支原体感染及耐药情况,为临床选择治疗支原体感染的抗生素提供参考依据。方法:采用支原体分离、鉴定、计数、药敏试剂盒检测拟诊为NGU患者的解脲脲原体(UU)和人型支原体(MH),并分析药敏试验结果。结果:630例患者中支原体总阳性率38.6%,以UU(30%)感染为主,男性感染率明显高于女性。药敏试验结果显示,UU、MH和UU+MH对药物的敏感性最高者依次为阿奇霉素和美满霉素,UU对氧氟沙星、司帕沙星和罗红霉素耐药性高,MH及UU+MH则对罗红霉素、红霉素和克拉霉素耐药性高。结论:UU成为本地区NGU的主要病原体,治疗本地区泌尿生殖道支原体感染可首选阿奇霉素和美满霉素。
Objective： To investigate urogenital mycoplasma infection and drug resistance in patients with non- gonoeoccal urethritis （NGU） in Wuhan city in order to provide a reference for choosing antibiotics in treating my- coplasma infection. Method： Mycoplasma separation, identification, counting, susceptibility kit were used to de tect Ureaplasma urealyticum （UU） and Mycoplasma hominis （MH） in suspected patients with NGU, and ana- lyzed the results of susceptibility test. Result： The total mycoplasma positive rate was 38.6% in 630 patients, and mainly was UU infection （30%）. The infection rate in men was significantly higher than women. The results of susceptibility test showed that azithromycin and minocycline were the most sensitive to UU, MH respectively and UU ＋ MH together. Ofloxacin, sparfloxacin and roxithromycin emerged drug resistance in UU. Roxithromycin, erythromycin and clarithromycin were not sensitive to MH or UU ＋ MH. Conclusion： UU is the main pathogen of NGU in this region. Azithromycin and minocycline could be the priority for the treatment of urogenital myco-plasma infection.
出处
《临床泌尿外科杂志》
2013年第12期920-922,共3页
Journal of Clinical Urology
关键词
尿道炎
支原体
抗生素
药敏试验
urethritis
mycoplasma
antibiotic
susceptibility test
