摘要
目的：探讨关罗华联合化疗在B细胞非霍奇金淋巴瘤治疗中的临床效果。方法：选取我院自2010年5月～2012年5月收治的56例B细胞非霍奇金淋巴瘤患者随机分为观察组与参考组，各为28例，观察组患者在化疗的基础上同时联合美罗华治疗，参考组患者只进行化疗治疗，比较2组患者的临床治疗效果、不良反应发生情况、患者5年内生存率。结果：观察组患者治疗有效率为92．9％，参考组患者治疗有效率为64．3％，2组数据比较差异显著，P〈0．05，有统计学意义；2组患者治疗中均未出现严重不良反应，P〉0．05，无统计学意义。观察组患者5年内生存率为85．7％，参考组患者5年内生存率为53．6％，2组数据比较有统计学意义，P〈0．05，有统计学意义。结论：给予B细胞非霍奇金淋巴瘤患者关罗华联合化疗治疗能够有效提高患者的治愈率，改善患者预后，同时不良反应发生率较低，安全有效，值得在临床进行推广。
Objective：To study the mabthera in combination with chemotherapy in B cell non - hodgkin＇s lymphoma in clinical effect. Methods：our hospital from May 2010 to May 2012, 56 patients with B cell non - hodgkin＇s lymphoma were treated randomly divided into observation group and reference group, 28 cases in the observation group of patients in the chemotherapy with mabthera therapy at the same time, on the basis of the reference group of patients for chemotherapy treatment, compared two groups of clinical curative effect and adverse reaction of patients with what is happening, and 5 years survival rate. Results： The observation group of patients treatment effective rate was 92.9% , the reference group of patients treatment effective rate was 64.3% , two groups of data was more significant difference, P 〈 0.05, there was statistical significance ; Two groups of treatment of the patients with no serious adverse reaction occurred, P 〉 0.05, no statistical significance. Observation group of patients within five years survival rate was 85.7% , the reference group 5 years survival rate was 53.6% , two groups of data comparison was statistically significant, P 〈 O. 05, with statistical significance. Conclusion ： B cell non - hodgkin＇s lymphoma patients＇ mabthera in combination with chemotherapy could improve the cure rate of patients, improve the prognosis of patients, and a lower incidence of adverse reactions, might be safe and effective, worth in clinical promotion.
出处
《中国伤残医学》
2013年第12期38-40,共3页
Chinese Journal of Trauma and Disability Medicine
关键词
美罗华
化疗
B细胞非霍奇金淋巴瘤
临床效果
Mabthera
Chemotherapy
B cell non - hodgkin＇s lymphoma
Clinical effect
