摘要
目的 :探讨急性呼吸衰竭患者尿中尿酸 (U UA)排泄变化及其对组织能量代谢状况的评价意义。方法 :2 1例急性呼吸衰竭患者均放置 Swan Ganz导管 ,连续 4日收集尿液并测定 2 4小时 UU A排泄量 ,采集动脉和混合静脉血进行血气分析 ,计算氧动力学指标。结果 :死亡组 UU A呈进行性增加 ,氧消耗对氧供给呈氧供依赖关系 ,动脉氧分压 /吸入氧浓度则从第 3日开始显著下降 (P<0 .0 5 ) ;存活组 U UA无明显变化 ,氧动力学表现为非氧供依赖关系。结论 :UU A排泄量增加是患者能量代谢不足的表现 。
Objective:To observe the changes in urinary uric acid (UUA) excretion in patients with acute respiratory failure (ARF) and to assess its significance in the evaluation of energy metabolism in these patients.Methods:Twentyone patients with ARF were included in the study.SwanGanz catheter was inserted into pulmonary artery in each patient.Urine was collected and UUA concentration was measured consecutively for 4 days.Arterial and mixed venous blood samples were collected and blood gas analysis was performed.Parameters of oxygen kinetics were analyzed accordingly.Results:The patients were divided into two groups according to the outcome.In nonsurvivor group,UUA increased progressively.Oxygen consumption(O 2) decreased gradually with the reduction of oxygen delivery (O 2).Oxygen supply dependency of O 2 on O 2 was observed.The ratio of arterial oxygen tension and inspired oxygen fraction decreased significantly ( P <0 05) from the third day.In survivor group,UUA did not change significantly and independence of O 2 on O 2 was observed.Conclusions:Increased UUA excretion indicates inadequancy of energetic metabolism in tissue cells.It is an useful indicator to reflect the existence of tissue hypoxia.
出处
《中国危重病急救医学》
CAS
CSCD
2000年第12期745-746,共2页
Chinese Critical Care Medicine
关键词
呼吸衰竭
尿酸
氧供依赖
缺氧
acute respiratory failure
uric acid
oxygen supply dependency
hypoxiat
