摘要
目的 :了解脑卒中患者血一氧化氮 (NO)和内皮素 (ET)含量 ,并探讨其与病程、病灶大小及预后的关系。方法 :采用硝酸还原酶法测定血清 NO的代谢产物 NO- 2 和 NO- 3 含量 ;采用特异性放射免疫法测定血浆ET含量。结果 :3种性质不同的脑卒中患者急性期血 NO、ET含量无差异 (P均 >0 .0 5 ) ,但与正常对照组比较均有显著性差异 (P均 <0 .0 1) ;血 NO均低于正常对照组 ,血 ET均高于正常对照组 ;与急性期相比 ,恢复期血NO含量均增加 ,ET含量均减少 (P均 <0 .0 1)。病灶越大者 NO含量越低 ,而血 ET含量却越高 (P均 <0 .0 5 )。NO与 ET二者间呈负相关关系 (P<0 .0 5 )。结论 :血 NO、ET可作为判断脑卒中病情轻重和估计预后的一种参考指标 ;血 NO、ET可能参与了脑卒中的疾病发展、演变过程 ;提示脑卒中患者急性期使用增加 NO合成或抗ET受体 A(ETR A )
Objective:To observe blood levels of nitric oxide (NO) and endothelin (ET) in patients with acute cerebral vascular disease (ACVD),and their relationship with disease course,lesion size as well as prognosis.Methods:Nitric acid reductase method was adopted to determine the metabolite of NO,the content of ET was measured by radioimmunoassay.Results:There were no differences in NO and ET levels among cerebral infarction,cerebral hemorrhage and subarachnoid hemorrhage (SAH, P >0 05).In the acute phase,NO level was lower and ET was higher in cerebral incidents than that in control groups (all P <0 01).In the convalescence phase,NO level was higher and ET was lower than that in the acute phase (all P <0 01).The bigger the lesion size was,the lower NO level and the higher ET level was (all P <0 05).There was a significant negative correlation between NO and ET levels (P <0 05).Conclusions:Blood NO and ET can serve as clinical markers for judging disease severity and prognosis.NO and ET may be involved in the development of acute cerebral vascular diseases.Our data also suggest that it probably be beneficial to use of drugs to induce NO synthesis or ET receptorA antagonist during the acute phase.
出处
《中国危重病急救医学》
CAS
CSCD
2000年第12期720-722,共3页
Chinese Critical Care Medicine
基金
浙江省卫生厅科技计划项目!(No.19980 6 0 1)
关键词
急性脑血管病
一氧化氮
内皮素
acute cerebral vascular disease
nitric oxide
endotheliD
