摘要
目的 :探讨果胶铋、雷尼替丁、痢特灵和四环素每日服 2次 ,2周疗法对确诊为幽门螺杆菌 (Helicobacterpy lori ,HP)阳性的十二指肠溃疡的疗效及费用分析。方法 :60例农村患者随机分成四联疗法组 ( 30例 )和新三联 (由奥美拉唑、克拉霉素、甲硝唑组成 )疗法组 ( 30例 ) ,服药前及停药 4周行胃镜检查和组织活检。结果 :改良果胶铋四联疗法的溃疡愈合率、HP根除率和不良反应出现率分别为 93.3%、86.7%和 2 0 .0 % ,而新三联组则分别为 96.6%、90 .0 %和16.6% ,2组比较均无显著差异 (P >0 .0 5 )。结论 :由雷尼替丁、果胶铋、痢特灵和四环素组成的每日服药 2次 ,连服 2周的四联疗法 ,对HP阳性十二指肠溃疡疗效好 ,价格便宜 ,适合山区农村医院推广。
Purpose: To compare the effect of two week bismuth pectin quadruple therapy (bismutn pectin, ranitidine, tetracycline, furazolidone) and one week triple therapy (omperazole, clarithromycin, metronidazole) on confirmed helicobacter pylori(HP) positive duodenal ulcer. Methods: 60 cases were randomly assigned to quadruple (n=30) or triple therapy groups(n=30). Endoscopy with biopsy histology was performed before and 4 weeks after the cessation of treatment. Results: The ulcer healing rate, HP eradication rate, and incidence of mild adverse effect were 93.3%, 86.7% and 30.0%, respectively in quadruple therapy group, and 96.6%,90.0% and 23.7% respectively in triple group. There was no significant difference between the two groups. Conclusions: Bismuth quadruple in effective in the treatment of HP positive duodenal ulcer, and has cheaper price.
出处
《临床消化病杂志》
2000年第6期267-268,共2页
Chinese Journal of Clinical Gastroenterology
基金
广东省医药资助科研课题 (No .A1 99860 5)
