摘要
目的 观察研制的壳聚糖生物活性敷料对创面愈合的影响.方法 选用10只清洁级Wistar大鼠,于脊柱两侧制备面积约2.0 cm×1.0 cm无菌创面及感染创面动物模型,设立同体对照,实验组用壳聚糖生物活性敷料覆盖,对照组用凡士林纱布（高渗盐水纱布）覆盖,于术后3、7、10、14 d观察创面感染、组织反应、肉芽生长及愈合情况,两组均定期换药直至创面愈合,比较两种敷料对创面愈合的影响.结果 无菌创面及感染创面愈合时间实验组分别为（9.6±1.5）d和（15.3±2.6）d,对照组为（14.6±2.1）d和（19.0±3.2）d,实验组的治疗效果明显优于对照组,差异有统计学意义（P＜0.05）.结论 研制的壳聚糖生物活性敷料具有控制创面感染及促进创面愈合的作用.
Objective To study the role of developed chitosan biological activity dressings on wound healing.Methods Establish 10 sterile wound and infection wound animal models by clean level Wistar rats on both sides of the spine preparation area of about 2.0 cm × 1.0 cm and Autologous comparison,all animal were divided into experimental group and control group,experimental group covered with chitosan bioactive dressing,control group covered with Vaseline gauze （hypertonic saline gauze）.We observed wound infection,tissue reaction,the growth of granulation and healing on 3,7,10,14 days after surgery.Both groups were regularly dressing until wound healing,comparing two dressing effect on wound healing.Results The wound healing time were （9.6 ± 1.5） and （15.3 ± 2.6） days in experimental group in sterile wound and infection wound,which were （14.6 ±2.1） and （19.0 ±3.2） days in control group.The therapeutic effect of experimental group was better than that of the control group,the difference was significant difference （P ＜ 0.05）.Conclusion Developed chitosan biological activity dressings can control infection and promote wound healing.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2013年第12期2680-2681,共2页
Chinese Journal of Experimental Surgery
关键词
生物活性
壳聚糖
敷料
创面愈合
Biological activity
Chitosan
Dressing
Wound healing
