摘要
目的观察舒心通脉方对心肌重构小鼠T淋巴细胞亚群的影响。方法将51只Balb/c小鼠随机分为6组(正常组、正常加中药中剂量组、模型组、中药低剂量组、中药中剂量组、中药高剂量组),采用腹主动脉结扎法建立心肌重构小鼠模型。予舒心通脉方灌胃干预30d,检测血清与心肌CD4+和CD8+含量。结果模型组小鼠血清与心肌的CD4+含量以及CD4+/CD8+值较正常组显著降低(P<0.05),中药中、高剂量组血清与心肌的CD4+含量以及CD4+/CD8+值较模型组显著上升(P<0.05)。结论 +/+失衡,可能有一定的改善心肌重构作用。
Objective To observe effect of Suxintongmai Recip on T cell subset of myocardium reconstitution rats. Methods 51 Balb/c rats were randomly divided into six groups（Normal group, Normal ＋ traditional Chinese medicine in dose of middle group, traditional Chinese medicine in dose of low, middle, high group）, The rat model of myocardium reconstitution was established by using the method of abdominal a orta ligation. Except Normal group, the rats was given Suxintongrnai- Recip by means of intragastric administration for 30 days,and the con- tent of CD4＋ and CD8 ＋ in blood serum and cardiac muscle tissue were detected. Results In the model group the content of CD4 ＋ and CIM / CD8＋ in blood serum and cardiac muscle tissue decreased significantly compared with those in the normal group（ P〈0. 05）. In the traditional Chinese medicine dose of middle,high group the content of CD4＋ and CD4＋/CI）8＋ in blood serum and cardiac muscle tissue rised significantly Compared with those in the model group（ P 〈0. 05）. Conclusion Suxintongmai - Recip could correct the CD4＋/CD8＋ imbalance of myocardium reconstitution rats, perhaps had partial effect on improving cardiac ventricle reconstitution.
出处
《中国中医药现代远程教育》
2013年第20期151-153,共3页
Chinese Medicine Modern Distance Education of China
