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右美托咪定对老年患者应用瑞芬太尼后痛觉过敏的影响 被引量：9

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摘要 目的探讨右美托咪定对预防老年患者应用瑞芬太尼后痛觉过敏的效应。方法择期全麻下行妇科手术老年患者40例，ASA分级Ⅰ～Ⅲ级，随机分为右美托咪定组（Ⅰ组）和对照组（Ⅱ组），每组20例。两组患者均采用静吸复合麻醉，术中靶控输注异丙酚、瑞芬太尼并吸人七氟醚，维持BIS40～60。两组患者分别于手术结束前30min静脉泵注右美托咪定0．6μg·kg^-1～·h^-1和0．9％氯化钠注射液。两组患者术后均采用芬太尼自控镇痛（PCIA）。记录两组患者自主呼吸恢复时间、苏醒时间、拔管时间，记录术后1h、4h、24hVAS和BCS评分；比较术后不良反应发生率；术后首次PCIA按压时间及术后PCIA按压次数。结果两组患者睁眼时间和拔管时间无统计学差异；与Ⅱ组比较，Ⅰ组术后1、4hVAS评分显著降低；BCS评分显著升高；术后躁动、寒战、恶心、呕吐发生率显著降低；术后首次PCIA按压时间明显延长；PCIA按压次数明显减少。结论右美托咪定可有效预防老年患者应用瑞芬太尼后痛觉过敏现象，且降低术后不良反应发生率，减少术后镇痛药用量。
作者 王东昕 杨静远 姜新 刘卓
机构地区 吉林省肿瘤医院麻醉科 吉林大学第一医院 吉林大学第三医院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2013年第23期5873-5875,共3页 Chinese Journal of Gerontology
关键词 右美托咪定 痛觉过敏 瑞芬太尼
分类号 R614 [医药卫生—麻醉学]
  • 相关文献

参考文献7

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共引文献93

同被引文献88

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引证文献9

二级引证文献62

中国老年学杂志
2013年 第23期

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