摘要
研究对9,9-二苯基芴的合成方法按照不同原料进行了概述,主要以芴、芴酮、联苯为常见原料制备9,9-二苯基芴。其中,制备9,9-二苯基芴最为经典有效的方法是以2-卤代联苯为起始原料,经格式试剂加成得到醇,而后傅氏反应得到9,9-二苯基芴。该方法虽然是二步反应,但是容易操作,原料较易得到,产品易提纯,收率高。
This paper we reviewed the synthesis of 9,9- diphenylfluorene. Raw materials included the fluorene,fluorenone and biphenyl. A general and efficient synthesis of 9,9- diphenylfluorene has been developed. This methodology is realized by a two steps Grignard addition and Friedel-Crafts cyclization reactions catalyzed by Lewis or Bronsted acid to form the desired fluorene rings. The method offered several advantages such as high yield,high selective,mild reaction condition,easily accessible starting materials,etc.
出处
《黑龙江科学》
2013年第9期21-23,共3页
Heilongjiang Science
基金
省财政基本科研业务费专项资助(CZ12BZPQ09)
关键词
芴
芴酮
联苯
9
9-二苯基芴
傅氏反应
Fluorene
fluorenone
biphenyl
9
9-diphenylfluorene
Friedel-Crafts reaction
