摘要
对环磷酰胺(CTX)化疗后的瓦克癌肉瘤大鼠采用胎肝细胞输注(FLI)观察骨髓造血功能的变化。FLI 组和 CTX+FLI 组骨髓造血细胞的~3H-TdR 掺入量分别高于生理盐水组和 CTX 组(P<0.01和 P<0.05),CTX+FLI 组外周血白细胞计数和网织红细胞计数明显高于 CTX 组(P<0.001和 P<0.05)。FLI 具有促进化疗后骨髓造血功能恢复的作用。
This paper reports the effect of fetal liver infusion(FLI)on the hematopoietic recovery of the bone marrow after cyclophosphamide(CTX)in rats bearing Walker carcinosarcoma 256(W_(256)).The results showed that the amount of ~3H-TdR incorporated into marrow hematopoietic cells in FLI group and CTX+FLI group was higher than that in control groups(P<0.01 and P<0.05 respectively).The peripheral white blood cell count(WBC)and reticulocyte count(Ret)in CTX+FLI group were higher than those in CTX group(P<0.001 and P<0.05 respectively).The data indicate that FLI may promote the reversal of the bone marrow depression caused by chemotherapy.
关键词
胎肝细胞
骨髓
造血功能
药物疗法
fetal liver infusion
cyclophosphamide
bone marrow hematopoiesis
Walker carcinosarcoma 256(W_(256))
