摘要
目的观察老年慢性阻塞性肺疾病急性加重期（AECOPD）患者治疗前后基质金属蛋白酶-9（MMP～9）、基质金属蛋白酶组织抑制剂1（TIMP-1）和白介素8（IL-8）浓度变化，探讨激素及B受体激动剂对治疗的影响。方法人选40例AEc0PD患者，随机分为4组，每组10例，分别给予常规、吸人激素、B受体激动剂和激素联合p受体激动剂等不同治疗，用ELISA分析检测各组血清和诱导痰中MMP-9、TIMP-1和IL-8的浓度。结果激素联合8受体激动剂治疗组治疗后血清及诱导痰上清液MMP-9、TIMP—1和IL-8浓度下降具有统计学意义（P〈0．05）。结论激素联合8受体激动剂可能是拮抗COPD气道炎症和气道重塑的有效治疗手段。
Objective To observe the change of metalloproteinase （MMP）-9, tissue inhibitor of metalloproteinase （TIMP）-I and interleukin（IL）-8 between pre-and post-treatment in elderly patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Furthermore, the effects of corticosteroid and 13 agonist were evaluated. Methods Forty patients with AECOPD were selected and randomly divided into four groups with 10 patients for each. Conventional treatment, inhaled corticosteroid, 13 agonist and inhaled corticosteroid combined with ]3 agonist were respectively administered to the different groups. The levels of MMP-9, TIMP-1 and IL-8 in the induced sputum and serum of the patients from each group were detected by ELISA. Results In the group treated with corticosteroid plus ]3 agonist, the levels of MMP-9,TIMP-1 and IL-8 in sputum and serum were lower in post-treatment than in pre treatment. The difference showed a statistically significant decrease （ P （0.05）. Conclusions Corticosteroid combined with 13 agonist may be the effective therapy to inhibit airway inflammation and remodeling in COPD.
出处
《国际呼吸杂志》
2013年第23期1770-1773,共4页
International Journal of Respiration
