摘要
目的了解急性脑炎／脑膜炎病例病毒感染病原谱构成及流行病学特征。方法在宜昌市选取4家城区和2家周边区县医院作为哨点医院，收集2006—2012年急性脑炎／脑膜炎病例血清和脑脊液标本，采用ELISA方法检测乙脑病毒（JEV）、柯萨奇病毒（COX）、埃可病毒（ECHO）、单纯性疱疹病毒I／Ⅱ型（HSV）、腮腺炎病毒（MuV）的IgM抗体。结果2006—2012年共检测病例2085份，JEV感染率呈逐年缓慢波动下降趋势，而MuV感染率呈逐年上升趋势。7～8月为病毒感染高峰。血清和脑脊液中JEVIgM抗体阳性率为2．49％（53／2085）。在698份患者血清标本中MuV、HSV、COX、ECHO的IgM抗体阳性率分别为20．63％，18．77％，10．17％，8．60％。结论MuV、HSV、COX、ECHO是宜昌市6所哨点医院急性脑炎／脑膜炎病例病毒性感染的主要病原，应加强此类病例的监测，特别是实验室病原学检测。
Objective To find out the epidemiological characteristics and viral pathogen spectra of acute meningitis/ encephalitis syndrome （AMES）cases. Methods Six sentinel surveillance hospitals from Yiehang city of Hubei province were selected,which included 4 hospitals at prefectural and 2 hospitals at county level respectively. The samples of serum and eerebrospinal fluid （CSF）were collected from AMES cases from 2006 to 2012, and sero-diagnosis by ELISA was performed for the specific IgM antibody of 5 kinds of virus. Results 2085 AMES cases were detected from 2006 to 2012. The infection rate of JEV showed a downtrend year by year, but the infection rate of MuV increased from 2009 to 2012. The reported AMES cases showed a peak from July to September. Of all samples,the specific IgM antibody against Japanese encephalitis virus （JEV）was detected, and the positive rate was 2.49% （53/2085 cases）. The positive rate for the specific IgM antibody against other four kinds of viruse was ： mumps virus （ MuV ） 20. 63%, herpes simplex virus （ HSV ） 18.77%,coxsackie virus （COX） 10. 17%, ECHO-viruses （ECHO） 8.60%. Conclusion MuV, HSV, COX and ECHO were the most important pathogens of viral infection for AMES cases in the six sentinel surveillance hospitals in Yichang city.
出处
《公共卫生与预防医学》
2013年第6期21-23,共3页
Journal of Public Health and Preventive Medicine
基金
卫生部与WHO流脑与乙脑监测合作项目(NO.WP/2006/CHN/IVD/1.1/001)
湖北省卫生厅科研基金指导性项目(NO.JX3C40/2007-2008)
