摘要
目的观察白蛋白结合型紫杉醇在晚期转移性乳腺癌二线及二线以上化疗中的效果和不良反应。方法2012年2月至2013年2月我院共收治晚期转移性乳腺癌21例，所有患者在复发转移后均接受过一线解救化疗。使用白蛋白结合型紫杉醇260mg／m2，3周1次，每2个周期评价1次疗效。结果4例部分缓解，8例稳定。21例均未发生过敏反应，主要不良反应是粒细胞减少和神经毒性。结论白蛋白结合型紫杉醇在晚期转移性乳腺癌二线及二线以上化疗中仍有较好疗效，毒性反应可耐受，且未发生过敏反应。
Objective To investigate the therapy effect and adverse reaction of the abraxane chemotherapy as a alternative plan in metastatic breast cancer. Methods Twenty-one patients with advanced metastatic breast cancer were selected as our subject. All the patients received rescue chemotherapy after relapse and metastasis. Abraxane were administrated with 260 mg/m2 3 weeks/time, and evaluated the effect in every two course of radiotherapy. Results Of 21 cases,4 cases were remission and 8 cases were with stable progress of cancer. No allergic reaction occurred. The majority adverse reaction were granulocytopenia and nerve toxicity. Conclusion Abraxane migh be considered as the alternate therapy medicine of metastatic breast cancer due to good curative effect,less toxicity reaction and no allergic reaction.
出处
《中国综合临床》
2013年第12期1320-1321,共2页
Clinical Medicine of China
关键词
紫杉醇
转移性乳腺癌
不良反应
Abraxane
Metastatic breast canoe
Adverse effect
