摘要
目的探讨人院时血清热休克蛋白（HSP）60、HSP65检测对冠心病患者1年内心血管事件的预测价值。方法选取南京医科大学附属无锡市人民医院和无锡市第二人民医院2009年11月至2011年2月心内科住院的89例患者作为研究对象，分为急性冠状动脉综合征（ACS）组50例、稳定型心绞痛（SAP）组19例、无冠心病（non—CHD）组20例。测定所有患者入院即刻血清中人HSP60、HSP65浓度。并对所有患者建立随访记录，观察1年内心血管事件的发生情况，并分析其与HSP60、HSP65之间的关系。结果成功随访84例，失访5例。1年内有心血管事件发生的患者共18例，血清HSP60[（1026．19±253．47）ng／L]、HSP65[（2573．95±768．75）ng／L]的浓度均明显高于无心血管事件发生的患者[（845．75±138．52）、（2076．38±385．46）ng／L]，差异有统计学意义（t值分别为2．49、2．58，P均〈0．05）。ACS组内有心血管事件发生患者血清中HSP60[（1162．73±249．14）ng／L]、HSP65[（2714．39±738．44）ng／L]的浓度亦均明显高于无心血管事件发生的患者[（892．55±204．62）、（2136．85±472．62）ng／L]，差异有统计学意义（t值分别为2．19、2．65，P均〈0．05）。经COX回归分析可见HSP65为急性冠状动脉综合征患者近期是否发生心血管事件的独立预测因子（RR=1．002，95％C11．000～1．004，P=0．035）。结论人HSP60、HSP65检测在冠心病预后中具有重要的价值，其中HSP65是预测急性冠状动脉综合征患者1年心血管事件发生的独立危险预测因子。
Objective To investigate the significance of heat shock protein 60 （HSP60） and heat shock protein 65 （HSP65） on prognosis acute coronary syndrome （ACS） within one year. Methods Eighty- nine hospitalized patients were collected from department of Cardiovascular disease ,the people＇s hospital of Wuxi city affiliated of Nanjing Medical University and the Second People＇s Hospital Wuxi City from November 2009 to February 2011 , and divided into ACS group （ n = 50）, stable angina pectoris （SAP） group （ n = 19） and non- CHD group（ n = 20）. HSP60, HSP65 levels in human serum were measured at the time of admission. The follow- up records of all patients were established to observe the occurrence of coronary events during one year, and analyzed its relationship between with HSP60, HSP65. Results Eighty-four cases were successful followed-up, and lost cases were 5. Eighteen patients occurred cardiovascular events within one year, and their content of serum HSP60 and HSP65 were significantly higher than that of without cardiovascular events （HSP60： （ 1026. 19 ± 253.47） ng/L vs. （ 845.75 ± 138. 52 ） ng/L, t = 2.49, P 〈 0.05 ; HSP65 ： （ 2573.95 ± 768.75 ） ng/L vs. （2076. 38 ±385.46） ng/L,t = 2. 58,P 〈 0.05 ）. In ACS group,the level of serum HSP60 and HSP65 of the patients occurred cardiovascular events was significant higher than that of without cardiovascular events, and there was significant difference（ HSP60 ： （ 1162. 73 ± 249. 14 ） ng/L vs. （ 892. 55 ±204. 62 ） ng/L, t = 2. 19, P〈0.05;HSP65：（2714.39 ±738.44） ng./L vs. （2136.85±472.62） ng/L,t =2.65,P 〈0.05）.COX regression analysis showed that HSP65 was an independent risk factor for recent cardiovascular events in patients with ACS （ RR = 1. 002,95 % CI 1. 000 - 1. 004, P = 0. 035 ）. Conclusion The detection of HSP60, HSP65 in prognostic coronary artery disease prognosis has important value, and HSP65 was an independent risk predictor of ACS in recent cardiovascular events within one year.
出处
《中国综合临床》
2013年第12期1261-1264,共4页
Clinical Medicine of China
