摘要
目的 :研究和评价氯沙坦与吲达帕胺或氢氯噻嗪合用降压疗效及对代谢的影响。方法 :选择 45例轻—中度原发性高血压患者 ,随机分成 3组 ,每组各 15例。氯沙坦组 :单用氯沙坦 5 0～ 10 0mg ,每日一次 ;氯沙坦与吲达帕胺合用组 :氯沙坦 5 0mg ,每日一次 ,加吲达帕胺 2 .5mg ,每日一次 ;氯沙坦与氢氯噻嗪合用组 :氯沙坦 5 0mg ,每日一次 ,加氢氯噻嗪 12 .5mg ,每日二次。三组疗程均为 12周。观察三组治疗前后的随测血压 (CBP)和 2 4小时动态血压 (ABPM)及生化指标。结果 :氯沙坦加吲达帕胺或加氢氯噻嗪组降压总有效率及随测血压、2 4小时动态血压的变化均明显优于氯沙坦单用组 ,且治疗前后心率和生化指标无明显改变。结论 :氯沙坦与吲达帕胺或氢氯噻嗪联合应用降压效果较单用氯沙坦更有效 。
Objective:To study the efficacy of losartan in combination with indapamide or hydrochlorothiazide in treatment of hypertension and their effects on metabolism. Method:Forty five patients were randomly divided into three groups:losartan alone (50～100 mg qd, n =15),losartan (50 mg qd) plus indapamide (2.5 mg qd) group( n =15),losartan (50 mg qd) plus hydrochlorothiazide (12.5 mg Bid) group( n =15). Three groups were all treated for 12 weeks. Casual blood pressure,24 hours ambulatory blood pressure, some biochemical parameters such as liver function, blood potassium, and blood uric acid were evaluated before and after treatment. Results:Both losartan plus indapamide group and losartan plus hydrochlorothiazide group had better effects than losartan alone group in reducing blood pressure. No bioch0emical parameter changes were observed in three groups after treatment. Conclusions:Losartan in combination with indapamide or hydrochlorothiazide are more effective than losartan in the treatment of the patients with mild to moderate hypertension. No adverse effects on metabolism in treated patients were found.
出处
《高血压杂志》
CSCD
2000年第4期324-326,共3页
Chinese Journal of Hypertension
关键词
氯沙坦
吲哒帕胺
氢氯噻嗪
高血压
治疗
losartan
indapamide
hydrochlorothiazide
hypertension
combination ther
