摘要
目的：探讨Ｐ选择素在急性脑梗死中的变化。方法：采用流式细胞术对４３例脑梗死患者发病１～３天及发病后１０～１４天进行Ｐ选择素的研究。结果：（１）急性脑梗死患者发病后１～３天内其血小板表面Ｐ选择素表达量较对照组显著增高（Ｐ＜０．０１）。（２）发病后１０～１４天内的血小板表面Ｐ选择素表达量较对照组增高（Ｐ＜０．０１）。（３）发病后１０～１４天的Ｐ选择素表达量较发病后１～３天显著下降（Ｐ＜０．０１）。结论：Ｐ选择素在急性脑梗死的发病过程中具有重要作用。
Objective: To observe the changes of p-selectin in peripheral blood in patients with acute cerebral infarction. Methods: We measured the levels of P-selectin in 43 patients in 1th-3th day and 10th-14th day after orset by flow cytometry. Results: The levels of P-selectin on platelets in peripheral blood in paients in both 1th-3th day and 10th - 14th day after the onset were significantly higher than that of controls (P < 0. 01). Concluson: P-selectin plays an important role in the pathogenesis of acute cerebral infarction.
出处
《卒中与神经疾病》
2000年第4期207-208,共2页
Stroke and Nervous Diseases
关键词
脑梗死
P选择素
流式细胞术
Cerebral infarction P-selectin Flow cytometry
