摘要
目的 :比较国产卡维地洛与柳胺苄心定治疗轻、中度原发性高血压患者的降压疗效和安全性。方法 :轻中度原性高血压患者 5 0例 ,随机分为卡维地洛组 (n=2 5 )与柳胺苄心定组 (n =2 5 ) ,分别口服卡维地洛 10mgbid,柳胺苄心定 5 0mgbid (均 8AM与 8PM)。治疗 2周后卡维地洛组 9例与柳胺苄心定组 4例因血压降低不满意 (舒张压>90mmHg)而分别增加剂量到 2 0mg和 10 0mgbid。共观察4周。结果 :卡维地洛组舒张压下降 11.2± 6 .7mmHg(P <0 0 1) ,收缩压下降 6 .9± 16 .2mmHg。柳胺苄心定组舒张压下降 1.1± 6 .2mmHg(P <0 0 1)。卡维地洛组总有效率 88%与柳胺苄心定组 84%相似。两组用药前后心率、血糖及血清胆固醇、甘油三酯均无明显变化 ;卡维地洛组HDL虽明显下降 ,但仍在正常范围内 ,不良反应少。结论 :国产卡维地洛治疗高血压的疗效与对照药柳胺苄心定相似 ,其疗效确切 ,不良反应少 ,耐受性好。
Aim:To compare the efficacy and side effect of domestic carvedilol and labetalol in the treatment of essential hypertension. Methods:Fifty mild to moderate hypertensive patients were randomly allocated to treatments with either carvedilol group(10～20 mg bid, \%n\%= 25) or labetalol group(50～100 mg bid, \%n\%= 25) respetively for 4 weeks. Results:After 4 weeks of administration, systolic and diastolic blood pressure decrease significantly by 11.2±6.7 mmHg and 6.9±16.2 mmHg in carvedilol group while only diastolic blood pressure decrease significantly by 11.1±6.2 mmHg in labetalol group. There were no significantly changes in heart rate in two groups durinng trial. The total effective rate of the two groups were 88% and 84%, and side effects were mild during the trial. Conclusion:Domestic produced carvedilol is an efective,safe,and well tolerated antihypertensive drugs in patients with mild to moderate essential hypertension.
出处
《高血压杂志》
CSCD
2000年第4期332-333,共2页
Chinese Journal of Hypertension
关键词
高血压
卡维地洛
柳胺苄心定
治疗
hypertension
carvedilol
labetalol
efficacy
security
