摘要
目的通过对初发的青壮年甲状腺功能亢进症(甲亢)患者的骨密度(BMD)的测定,研究甲亢患者骨代谢的特征。方法采用双能X线吸收法对我院369例初发未经治疗的青壮年甲亢患者组和148名健康对照组进行腰椎L2-4,股骨近端的BMD检测,同时测定甲状腺功能、AKP、PTH、CT、24 h尿钙、血钙等。结果比较甲亢组与健康对照组的FT3、FT4和TSH差异有统计学意义(P<0.01),甲亢组的血钙、PTH和CT与对照组比较无统计学差异(P>0.05);甲亢骨量正常组24 h尿钙与对照组比较差异无统计学意义(P>0.05),而甲亢骨量异常组24 h尿钙与对照组比较有显著性差异(P<0.05);甲亢患者BMD与血清FT3、FT4呈负相关,与TSH呈正相关。结论通过甲状腺功能、骨密度及骨代谢指标的研究分析,发现甲亢将导致青壮年骨量减少和骨质疏松,因此在治疗甲亢时,不应忽略对骨质疏松的预防。
Objective To study the characteristics of bone metabolism by detecting bone mineral density （BMD） of young patients with hyperthyroidism. Methods The BMD of lumbar L2-4 and proximal femur in 369 cases of untreated patients with hyperthyroidism and 148 healthy controls were detected by dual-energy X-ray absorptiometry. The thyroid function, AKP, PTH, CT, 24 h urinary calcium, serum calcium were also detected. Results Comparison of FT3, FT4 and TSH between hyperthyroidism group and control group, which had statistically significant difference （P0.05）. There were no significant difference of 24 h urine calcium in hyperthyroidism bone mass normal group and control group （P〉0.05）. And 24 h urine calcium in hyperthyroidism abnormal bone mass group and the control group were significant difference （P〈0.05）. The BMD were negatively correlated with serum FT3, FT4 in hyperthyroidism patients, and positively correlated with TSH. Conclusion It was found that hyperthyroidism could cause bone loss and osteoporosis in young adults through the analysis of thyroid function, BMD and bone metabolism. So the prevention of osteoporosis should not be ignored in the treatment of hyperthyroidism..
出处
《分子诊断与治疗杂志》
2013年第6期382-384,共3页
Journal of Molecular Diagnostics and Therapy
基金
云南省卫生科技计划资助项目(2010NS010)
