摘要
目的探讨疑病症患者述情障碍与事件相关电位P300相关性。方法随机将年龄在18~65岁之间符合ICD-10疑病症诊断标准患者35例作为研究组,选择35例健康者作为对照组。两组均给予多伦多述情障碍20个条目量表(TAS-20)测评和P300检测,并将结果加以分析、比较。结果与对照组相比,研究组PZ点N1、P2、N2、P3潜伏期明显延长(P<0.05或<0.01),研究组PZ点N2、P3波幅明显延长(P<0.05或0.01);研究组TAS-20总分及各因子分均高于对照组(P<0.05或<0.01);PZ点N2、P3潜伏期与TAS-20总分及各因子分呈正相关(r=0.34~0.47,P<0.05或<0.01),PZ点N2、P3波幅与TAS-20总分及各因子分值则呈负相关(r=-0.31^-0.49,P<0.05或<0.01)。结论疑病症患者述情障碍可能与认知功能受损有关。
Objective To investigate the relationship between alexithymia and event-related potential P300 in patients with hypochondria disorder. Methods A total of 35 patients （ among 18 - 65 years old） met with ICD - 10 for hypochondria disorders criteria were recruited as research group. 35 normal healthy person were selected as control group. Toronto alexthymia scale - 20 （ TAS - 20） was employed to investigate the alexithymia of the subjects. P300 potentials was employed to investigate the cognitive ability of the subjects. A comparison was made between patients and healthy subjects. Results The latencies of PZ were significantly longer in patients with hypochondria disorder than those in the normal controls（ P 〈 0.05 or 0.01 ）, the amplitudes of PZ were significantly lower in patients （P 〈 0.05 or 0.01 ）. The three factors＇scores and the total score of TAS - 20 test in patients with hypochondria disorder were significantly lower than those in the normal controls（P 〈 0.05 or 0.01 ）. There were significant correlations between the latency of P300 and the three factors scores and the total score of TAS - 20 as well as between the amplitude of P300 and the three factors scores and the total score of TAS - 20 ： The latency of PZ was positively correlated with the factors scores （ r = 0. 34 - 0. 47, P 〈 0.05 or 0.01 ） and amplitude of PZ was negatively correlated with the TAS - 20 scores （ r = -0. 31 -0.49, P 〈 0.05 or 0.01 ）. Conclusion Alexithymia of patients with hypochondria disorders maybe have the correlation with cognitive impairment.
出处
《中国健康心理学杂志》
2013年第11期1621-1623,共3页
China Journal of Health Psychology
关键词
疑病症
述情障碍
认知功能
事件相关电位P300
Hypochondria disorders
Alexithymia
Cognitive function
Event-related potential P300
