摘要
目的探讨支气管肺泡灌洗治疗难治性肺炎患者及其血清C反应蛋白和降钙素原两项炎性指标的应用价值。方法268例难治性肺炎患者分为灌洗组与对照组，两组进行疗效和细菌清除率的比较，并研究血清C反应蛋白和降钙素原两项指标与疗效、预后的关系。结果灌洗组的细菌清除率高于对照组（65．9％VS38．9％，x^2=16．20，P〈0．0016）；灌洗组患者的疗效明显好于对照组，治愈率提高6．34％，显著率提高10．85％；血清C反应蛋白和降钙素原水平变化是良好的预后指标。结论支气管肺泡灌洗和血清C反应蛋白及降钙素原指标对于难治性肺炎患者具有重要的临床应用价值。
Objective To evaluate the application of bronchoalveolar lavage （BAL） and usefulness of serum C-reactive protein and procalcitonin as the inflammatory indicators in patients with refractory pneumonia. Methods 268 patients with refractory pneumonia were divided into BAL group and control group. The clinical efficacy and the bacterial removal rate between two groups were compared. The relationships between the changes of the inflammatory indicators and the progression and prognosis of disease were analyzed. Results The bacterial removal rate in BAL group was higher than that in control group （65.9 % vs 38.9 %, Xz = 16.20, P 0. 001 6）. BAL markedly improved clinical efficacy of refractory pneumonia, the cure rate and the significant rate in BAL group increased by 6.34% and 10.85% compared to control group. The serum C-reactive protein and procalcitonin were good indicators of the prognostic development of refractory pneumonia. Conclusions Application of BAL and the serum C-reactive protein and procalcitonin as the inflammatory indicators has significant clinical value for patients with refractory pneumonia.
出处
《国际呼吸杂志》
2013年第22期1707-1710,共4页
International Journal of Respiration
关键词
支气管肺泡灌洗
难治性肺炎
C反应蛋白
降钙素原
Bronchoalveolar lavage
Refractory pneumonia
C-reactive protein
Procalcitonin
