摘要
目的 :探讨射频消融 (RFCA)对血小板聚集功能的影响及其发生机理 ,评价肝素对此影响的作用。方法 :以 40例室上性心动过速患者为对象 ,分为肝素组 (A组 )和空白对照组 (B组 )。在不同时间测定血小板聚集率 (PAG)及血栓素 B2 (TXB2 )。结果 :RFCA术后 PAG和 TXB2 A组分别由41 .1 3± 1 3.1 0 %和 6 9.77± 1 7.6 0 ng/ L上升到 6 9.2 3± 1 5 .46 %和 97.1 5± 2 3.6 9ng/ L ;B组分别由 41 .99± 1 1 .1 2 %和 74.76± 1 1 .78ng/ L 上升到 79.31± 1 6 .85 %和 1 1 0 .2 4± 1 5 .41 ng/ L;P均 <0 .0 0 1 ) ,并且术后不能很快降至正常。术中肝素化能降低 RFCA术前、术后血小板聚集功能改变的幅度 ,A组变化率分别为 75 .45± 42 .31 %和 40 .1 4± 1 1 .98% ,B组为 91 .75± 2 1 .43%和 48.47±1 4.0 4% (P均 <0 .0 1 )。结论 :RFCA可引起血小板聚集功能的增高 ;抗凝治疗对预防 RFCA术后血栓栓塞并发症的产生有潜在的好处。
Objective:To study the mechanism of changes of platelet aggregability(PAG) in patients undergoing radiofrequency catheter ablation(RFCA) and to observe the inhibition effect of heparin on PAG and thromboxane B 2(TXB 2)of the blood samples.Methods:Forty patients with supraventricular tachycardia under different treatment were observed and divided into heparin group(group A) and control group(group B).Results:PAG and TXB 2 were increased clearly after FRCA(group A:41.13±13.10% and 69.77±17.60 ng/L to 69.23±15.46% and 97.15±23.69 ng/L;group B:41.99±11.12% and 74.76±11.78 ng/L to 79.31±16.85% and 110.24±15.41 ng/L; P <0.001) and PAG did not return to the baseline quickly.Introvenous heparin during operation can reduce the platelet aggregability caused by RFCA(the changed rate of group A: 75.45 ±42.31% and 40.14±11.98%;group B:91.75±21.43% and 48.47±14.04%; P <0.01).Conclusion:RFCA can cause the increasing of platelet aggregability and the flat respones of platelet aggregability after anticoagulated therapy provides evidence of the potential benifit in preventing thromboembolism after ablation.
出处
《浙江大学学报（医学版）》
CAS
CSCD
2000年第6期260-263,共4页
Journal of Zhejiang University(Medical Sciences)
关键词
血小板聚集
肝素
药理学
导管射频消融术
Platelet aggregability/drug eff
Thromboxane B 2/drug eff
Heparin/pharmacol
Catheter ablation
