摘要
目的 :研究大鼠急性出血坏死性胰腺炎 (牛磺胆酸钠胰胆管注射诱导 )细菌移位及其机制和茵陈蒿合承气汤的影响。 方法 :大鼠分成模型组、中药防治组、假手术组。术后观查外周血、门静脉血内毒素水平 ;肝、脾、胰、肠系膜淋巴结细菌移位率 ;盲肠内容物需氧菌总量和革兰阴性杆菌菌量 ;肠推进功能。 结果 :急性出血坏死性胰腺炎时外周血和门静脉血内毒素水平显著升高 ;肝、胰、肠系膜淋巴结组织细菌移位率显著升高 ;盲肠需氧菌总量和革兰阴性杆菌量显著升高 ;肠推进功能降低。应用茵陈蒿合承气汤能显著改善上述指标。 结论 :急性出血坏死性胰腺炎时存在细菌移位 。
To investigate the mechanism of bacterial translocation in acute hemorrhagic nerotizing pancreatitis(AHNP) in rats and the effects of Yin Chen Hao He Cheng Qi Decoction Methods:AHNP was induced by intraductal infusion of sodium taurocholate.Rats were divided into model group,treatment group and control group.After 48 hours, endotoxin concentration of peripheral and portal blood,quality culture of the liver,spleen,pancreas and mesenteric lymphnodes quantity culture of cecum and intestinal transit were observed.Results:In AHNP,the endotoxin concentration in peripheral and portal blood, the rates of bacterial translocation to organs and the quantity culture of cecum increased significantly and the intestinal transit decreased significantly.Yin Chen Hao He Cheng Qi Decoction could significantly improve the above indexes.Conclusion:Yin Chen Hao He Cheng Qi Decoction can reduce the incidence of bacterial translocation in rats with AHNP.
出处
《中国中西医结合外科杂志》
CAS
2000年第6期380-383,共4页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
急性出血坏死性胰腺炎
细菌移位
茵陈蒿合承气汤
acute hemorrhagic necrotizing pancreatitis,bacterial translocation,Yin Chen Hao He Cheng Qi decoction
