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麝香保心丸对冠心病患者心率变异性与射血分数的干预及其机制探讨 被引量:4

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摘要 目的了解冠心病不同心脏功能状况时自主神经功能活动的变化特点及加用麝香保心丸后的改善情况。方法对110例冠心病患者进行心率变异性(HRV)时域分析,并进行规范治疗。对照组按西药规范治疗,治疗组加用麝香保心丸口服,每日3次,每次2粒。治疗期为半年。监测治疗前后24h全部正常心动周期的标准差(SDDN),24h每5min正常R-R间期平均值标准差(SDANN),连续正常R-R间期差值的均方根(rMSSD),24h内每5min节段正常R-R间期标准差的平均值(SDNN5),两个相邻RR间期标准差>50ms的心搏数占所分析信息间期内心搏数的百分比(PNN50)。并以心脏彩超探测出心脏射血分数(EF)前后的差异,分析心率变异性各指标治疗前后的差异及其与射血分数的相关性。结果治疗前EF<50%患者HRV中的SDNN,SDNN5,PNN50较EF≥50%患者明显降低,并有一定相关性。而SDANN,rMSSD等指标无明显变化。治疗后麝香保心丸组SDNN5,rMSSD,PNN50较常规治疗组的HRV有进一步下降(P<0.05)。结论冠心病心衰患者HRV相关指标下降,麝香保心丸通过多种机制能够改善心脏功能,调节自主神经,防止心脏性猝死的发生。
机构地区 武汉市武东医院
出处 《中西医结合心脑血管病杂志》 2013年第11期1320-1321,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
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二级参考文献22

共引文献92

同被引文献49

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