摘要
实验以己二酸二甲酯为起始原料,经迪克曼缩合、羟醛缩合、甲基化、脱羧、再甲基化、加氢还原得到标题化合物,产物总收率达50.3%。中间体及目标产物结构经1HNMR表征。该工艺路线避免了副反应的发生,适合工业化生产。
5 - [ （ 4-Chlorophenyl ） methyl ] -2,2-dimethylcyclo-pentanone was prepared via Dieckmann condensation, Aldol reaction, methylation, deearboxylation, methylation and cata- lytic hydrogenation reaction using dimethyl adipate as raw. The total yield of the product can be up to 50. 3%. The struc-tures of the intermediates and the target compound were con-firmed by t HNMR. Side reaction can be avoided in this route, so it is suitable for industrial production.
出处
《化学试剂》
CAS
CSCD
北大核心
2013年第11期1039-1041,共3页
Chemical Reagents
基金
江苏省优势学科资助
