摘要
【目的】探讨在甲状腺癌再手术中应用纳米炭混悬液对甲状旁腺保护的作用与价值。【方法】选取2011年2月至2012年8月湖南省人民医院乳腺甲状腺外科25例甲状腺癌再手术患者，随机分为实验组（纳米炭组）12例和对照组13例，实验组在术中先向残余甲状腺或癌灶周围注射纳米炭0．3～0．5mL不等，对照组不使用纳米炭，观察两组辨别甲状旁腺和淋巴结的差异。【结果】实验组使再手术的甲状腺癌患者的甲状旁腺负显影与第Ⅵ区淋巴结黑色显影形成鲜明对比率达91．7％，明显高于对照组的23．1％，两组比较有显著性差异，而且术后一过性的甲状旁腺功能减退的并发症在实验组亦有显著降低（P〈0．05）。实验组清扫的中央区淋巴结等于或大于10个的为75％（9／12），显著高于对照组的30．8％（4／13），两组比较差异有显著性（P〈0．05）。【结论】纳米炭对甲状腺癌再手术中的甲状旁腺的负显影和淋巴结的黑染，使甲状旁腺易于识别和保护并降低一过性甲状旁腺功能减退的并发症，有利于彻底清扫中央区淋巴结。
[Objective] To explore the role and value of carbon nanoparticles suspension in thyroid carcinoma reoperation for protecting parathyroid gland. [Methods] Totally 25 patients undergoing thyroid carcinoma reoperation in department of breast and thyroid surgery of Hunan provincial people＇s hospital from Feb. 2011 to Aug. 2012 were chosen and randomly divided into experimental group（carbon nanoparticles group, n = 12） and control group（ n =13）. The experimental group was injected with 0.3-0.5 mL carbon nanoparticles in residual thyroid or tumor lesion during surgery, while the control group was not given carbon nanoparticles.The difference between parathyroid gland and lymph node of two groups was observed. [Results]The bright contrast ratio of negative development of parathyroid gland to black development at Ⅵ region of lymph node in patients with thyroid carcinoma reoperation in experiment group was 91.7%, which was obviously higher than that of control group（23.1 %）, and there was significant difference between two groups. And the incidence of postoperative complications such as transient hypoparathyroidism in experiment group also decreased significantly（ P 〈0. 05）. In the experimental group, the percentage of central lymph node dissection with equal or greater than 10 in experiment group was 75 % （9/12）, which was significantly higher than that in control group （30.8%）, and there was significant difference（ P〈0.05）. [Conclusion] In thyroid carcinoma reoperation,carbon nanoparticles for negative development of parathyroid gland and black dye of lymph node can make parathyroid gland easy to be identified, and protect and reduce the incidence of complications such as transient hypoparathyroidism, and is conducive to thoroughly clean the central lymph nodes.
出处
《医学临床研究》
CAS
2013年第10期1997-2000,共4页
Journal of Clinical Research
基金
晓庄学院第一附属医院（省人民医院）仁术基金课题资助
关键词
甲状腺肿瘤
纳米技术
再手术
Thyroid Neoplasms
Nanotechnology
Reoperation
