摘要
目的：探讨前列地尔对早期糖尿病肾病（DN）患者血清细胞因子的影响。方法：将59例早期DN患者随机分为对照组（29例）和观察组（30例）。对照组在常规降糖治疗的同时，给予缬沙坦胶囊（代文）80mg，每日一次；观察组基础治疗同对照组，另将前列地尔注射液10肛g加入100～250mL生理盐水中静脉点滴，每日一次，疗程均为2周。检测两组治疗前后血清白细胞介素-6（IL-6）、肿瘤坏死因子-a（TNF—a）、尿微量白蛋白排泄率（UAER）、空腹血糖（FPG）、血肌酐（Scr）、尿素氮（BUN）、血脂等指标的变化。结果：治疗后，两组UAER较治疗前明显改善，观察组改善更明显（P〈0．05），其他生化指标无明显变化（P〉0．05）；与治疗前比较，两组患者治疗后血清IL-6、TNF—a水平均下降（P〈0．05），观察组下降更为明显（P〈0．01）。结论：前列地尔可能通过减低血清IL-6、TNF—a的表达，阻滞炎症反应，起到对糖尿病肾病的保护作用。
Objective： To observe the effect of alprostadil on serum inflammatory factors of pa- tients with early diabetic nephropathy （DN）. Methods：A total of 59 cases of early DN were randomly di- vided into control group （29 cases） and treatment group （30 cases）. Plus conventional hypoglycemic thera- py, patients in control group were given valsartan capsules （Diovan） 80 mg, once daily; besides basic treatment patients in the treatment group were given intravenous drip of alprostadil injection 10 μg with 100-250 mL normal saline, once a day, for 2 weeks. Serum levels of interleukin-6 （IL-6）, tumor necrosis factor -a （TNF-a）, urinary albumin excretion rate （UAER）, fasting blood glucose （FPG）, serum creati- nine （Scr）, blood urea nitrogen （BUN）, the changes of blood lipid indexes were observed and compared beore and after the treatment. Results. After treatment, UAER was significantly improved, and the ira- provement was more s groups （P〈0.05）, an tg d nificant in treatment group~ the serum IL-6, TNF-a levels were decreased in two the decrease of the treatment group was more significant than the control group （P〈0.01）. Oonclusion. Alprostadil may reduce the serum IL-6, TNF-a to block inflammation, and have protective effect on diabetic nephropathy.
出处
《海南医学院学报》
CAS
2013年第12期1685-1687,1690,共4页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210896)~~
