摘要
目的:调查原发性高血压(EH)伴阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的心血管危险因素,为探讨心血管危险的预防措施提供借鉴。方法:将我院收治的132例EH伴OSAHS患者,按照是否发生心血管危险进行对比研究,采用问卷形式收集所有患者临床资料,统计分析导致心血管危险的单因素是否有显著意义,进行多因素Logistic分析,根据OR值判断更具有独立作用的高危因素。结果:10个调查因素中8个单因素进入多因素分析,非条件Logistic多因素回归分析统计显示,BMI(β=1.224,OR=1.922)、血压分级(β=1.119,OR=2.138)、OSAHS分度(β=1.415,OR=2.784)、高血脂(β=1.388,OR=1.763)、家族遗传病史(β=1.375,OR=1.863)是具有独立作用的高危因素。结论:EH伴OSAHS患者发生心血管危险的因素主要与血压分级、高血脂及家族遗传病史等相关,通过控制以上指标能显著降低心血管危险的发生率。
Objective： To investigate the cardiovascular risk factors in essential hypertension （EH） patients complicated with obstructive sleep apnea hypopnea syndrome （OSAHS）. Methods： Data of 132 pa- tients with EH complicated with OSAHS were comparatively analyzed according to occurrence of cardio- vascular risk events. Questionnaire was used to collect clinical data for statistical analysis; all the factors were given multi-factor logistic regression analysis in order to find out which factors played independent roles. Results： Among 11 factors, 8 factors were significantly associated with the cardiovascular risk, multivariate logistic regression revealed that factors including BMI （β= 1. 224, OR= 1. 922）, blood pressure classification （β= 1. 119, OR= 2. 138）, severity of OSAHS （β= 1. 415, OR = 2. 784）, high cholesterol （β =1. 388, OR=I. 763）, family genetic history （β=1. 375, OR=1. 863）, were significant risk factors. Oon- clusions： Blood pressure classification, high cholesterol and family genetic history were risk factors related with the occurrence of cardiovascular risk events, prevention of these factors can decrease incidence of car- diovascular risk events.
出处
《海南医学院学报》
CAS
2013年第12期1659-1662,共4页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210882)~~
