摘要
目的 探讨血清肝型脂肪酸结合蛋白（L-FABP）与非酒精性脂肪性肝病（NAFLD）患者疾病严重程度及脂代谢相关临床生化指标的相互关系.方法 选择96例NAFLD患者（观察组）及100例健康体检者（对照组）,用酶联免疫吸附法测定血清L-FABP及血生化指标,超声判定病变程度,同时计算体质指数（BMI）、腰臀比（WHR）及稳态模型评估法胰岛素抵抗指数（HOMA-IR）.结果 观察组WHR、BMI、空腹血糖（FBG）、三酰甘油（TG）、丙氨酸氨基转移酶（ALT）、HOMA-IR及L-FABP水平明显高于对照组,差异均有统计学意义（P＜0.05）.相关性分析结果表明,L-FABP水平与ALT（r=0.735）、TG（r=0.728）、FBG（r=0.681）、WHR（r=0.713）、BMI（r=0.699）、HOMA-IR（r=0.673）均呈正相关（P＜0.05）,与HDL-C呈负相关（r=-0.607,P＜ 0.05）.对照组L-FABP水平为（15.42±2.51） g/L,轻度NAFLD为（15.96±2.92） g/L,中度NAFLD为（17.48±3.91） g/L,重度NAFLD为（25.14±5.37） g/L.重度NAFLD患者L-FABP水平与对照组及轻、中度NAFLD患者比较差异均有统计学意义（P＜0.05）.结论 重度NAFLD患者血清L-FABP水平明显增高,L-FABP水平与一些肝功能生化指标有关.
Objective To investigate the correlation between liver-type fatty acid binding protein （L-FABP） and nonalcoholic fatty liver disease （NAFLD） extent and other clinical parameters.Methods Ninety-six patients of NAFLD （NAFLD group） and 100 cases of healthy controls （control group） were selected.The levels of serum L-FABP and blood biochemical parameters were measured by enzyme-linked immunosorbent assay.The lesion degree was assessed by ultrasound.The body mass index （BMI）,waist to hip ratio （WHR） and homeostasis model assessment insulin resistance index （HOMA-IR） were calculated.Results The WHR,BMI,fasting plasma glucose （FBG）,triglycerides （TG）,alanine aminotransferase （ALT）,HOMA-IR and L-FABP in NAFLD group were higher than those in control group,there were statistical differences （P 〈 0.05）.The result of correlation analysis showed L-FABP level was positively related with ALT,TG,FBG,WHR,BMI,HOMA-IR （r =0.735,0.728,0.681,0.713,0.699,0.673 ;P 〈0.05）,and negative correlation with HDL-C （r =-0.607,P 〈 0.05）.The L-FABP level in control group was （15.42 ± 2.51） g/L,mild NAFLD was （15.96 ± 2.92） g/L,moderate NAFLD was （17.48 ± 3.91） g/L,serious NAFLD was （25.14 ± 5.37） g/L.There was statistical difference in L-FABP level between serious NAFLD and control group,mild NAFLD,moderate NAFLD （P 〈 0.05）.Conclusion Serum L-FABP level of serious NAFLD patient significantly increases,and L-FABP level is related with biochemical parameters of liver function.
出处
《中国医师进修杂志》
2013年第30期16-18,共3页
Chinese Journal of Postgraduates of Medicine
关键词
脂肪酸结合蛋白质类
非酒精性脂肪肝
Fatty acid-binding proteins
Nonalcoholic fatty liver disease
