摘要
目的 观察山莨菪碱对环孢素A(CsA)肝毒性的影响。方法 SD大鼠分 4组 :对照组、CsA组、CsA +小剂量山莨菪碱组、CsA +大剂量山莨菪碱组。用药前、用药 1周及 2周分别检测血甘氨胆酸 (GCA)、胆红素、白蛋白、丙氨酸氨基转移酶 (ALT)、天冬氨酸转氨酶 (AST)及碱性磷酸酶 (ALP)。用药 2周后检测肝组织甘油三酯、脂质过氧化物 (LPO)、超氧化物歧化酶 (SOD)、还原型谷胱甘肽 (GSH)及细胞色素P45 0。结果 发现山莨菪碱可减轻CsA引起的下述异常 :血GCA、胆红素、白蛋白 ,肝匀浆LPO、GSH及细胞色素P45 0。
Objective To study the effect of anisodamine on the cyclosporine A(CsA) hepatotoxicity. Methods SD rats were divided into 4 groups: control, CsA, CsA+anisodamine 5 mg·kg -1 ·d -1 and CsA+anisodamine 20 mg·kg -1 ·d -1 . The serum glycocholic acid(GCA), bilirubin, albumin, alanine aminotransferase(ALT), aspartate aminotransferase(AST) and alkaline phosphatase (ALP) were assess before and 1, 2 weeks after the of drugs. The liver homogenate triglyceride,lipid peroxide(LPO), reduced glutathione(GSH), superoxide dismutase(SOD) and cytochrome P450(Cyt P450) were assessed by the end of the 2 week experiment. Results It was found that anisodamine could attenuate the consequent abnormalities caused by CsA i.e. the GCA, bilirubin and albumin in blood, and the LPO, GSH and Cyt P450 in liver. Conclusion Anisodamine can reduce the hepatotoxicity of CsA.
出处
《徐州医学院学报》
CAS
2000年第6期435-438,共4页
Acta Academiae Medicinae Xuzhou
基金
上海市科委科技发展基金资助课题(931931965)
关键词
山莨菪碱
环孢素A
肝毒性
预防
治疗
anisodamine
cyclosporine A
hepatotoxicity
prophylaxis
treatment
