摘要
为了确定妥曲珠利纳米乳的处方和制备工艺,选用液体石蜡、乙酸乙酯、大豆油、IPM、油酸为油相,RH-40、EL-40、OP-10、吐温-80、司盘-80为表面活性剂,乙醇、1,2-丙二醇、异丙醇、丙三醇、PEG-400为助表面活性剂,通过伪三元相图筛选制备妥曲珠利纳米乳的最佳处方。结果表明,油相为乙酸乙酯、表面活性剂为吐温-80,助表面活性剂为1,2-丙二醇可形成纳米乳。优化处方为表面活性剂:助表面活性剂:油相:水相=2∶1∶2∶5,增溶剂添加量为10%,在该处方下制备的妥曲珠利纳米乳稳定性良好。
To determine the prescription and preparation method of toltrazuril nanoemulsion,the liquid paraffin,ethyl acetate,soybean oil,IPM and oleic acid were selected as the oil phase; RH-40,EL-40,OP-10,Tween-80 and Span-80 were chosen as the surfactant; and alcohol,1,2-propanediol,ispropanl,glycerol and PEG-400 were the co-surfactant.The best prescription was acquired through the pseudo-ternary phase diagrams.The result shows that ethyl acetate,Tween-80 and 1,2-propanediol can facilitate the formation of nanoemulsion.The optimum prescription is surfactant：co-surfactant：oil phase：water phase =2∶1∶2∶5,with a solubilizer of 10%.And it shows that this prescription can prepare the stable toltrazuril nanoemulsion.
出处
《家畜生态学报》
北大核心
2013年第10期55-57,共3页
Journal of Domestic Animal Ecology
基金
山东省技术创新项目(201220916001)
关键词
妥曲珠利
纳米乳
制备
质量评价
toltrazuril
nanoemulsion
preparation
quality evaluation
