摘要
目的:通过检测分析血清及脑脊液中肿瘤坏死因子-ɑ(TNF-ɑ)及其受体在病毒性脑炎患儿中治疗前后的浓度变化,探寻TNF-ɑ在病毒性脑炎发病中的作用机制。方法:对象为本院患者中随机选取的15例重症与10例轻症患病毒性脑炎患儿和10例股疝患儿。用ELISA方法在治疗前测定血清和脑脊液以及在治疗后血清当中TNF-ɑ的浓度并进行比较分析。结果:患儿血清和脑脊液中TNF-ɑ浓度在轻症组和重症组中和治疗前相比明显升高,升高程度重症组大于轻症组,轻症组大于对照组(p<0.01),差异有统计学意义。治疗后,重症组和轻症组患儿中血清TNF-ɑ浓度与治疗前相比明显下降(p<0.01),统计学有显著差异。结论:病毒性脑炎患儿血清和脑脊液中TNF-ɑ水平与疾病严重程度呈正相关,治疗前浓度越高病情越严重。
Objective：Via detecting level changes of tumor necrosis factor- α（TNF -α） and its receptor in serum and cerebrospinal fluid, validating the mechanism of TNF- u in encephalitis. Methods：Encephalitis children involved 15 with severe（SVE） and 10 with mild（MVE） , 10 children with femoral hernia were included. The levels of TNF -α was detected before treatment using ELISA in serum and CSF of all children. Results： Before treatment, the TNF - α level in serum and CSF elevated significantly while compared with control group ; The serum and CSF TNF - α level in SVE group was higher than MVE group was, the difference was significant（ p 〈 0. 01 ）. After treatment, TNF-α decreased in both group of SVE and MVE compare with levels before treatment （ 〈 0. 01 ）. Conclusion ：The TNF- α level in serum increased in children with VE, the results indicate that the serum and CSF TNF - αlevel has an positive correlation with the severity of the disease.
出处
《中国伤残医学》
2013年第11期46-48,共3页
Chinese Journal of Trauma and Disability Medicine
关键词
脑炎
病毒性
肿瘤坏死因子-α
脑脊液
Viral encephalitis （VE）
Children
Tumor necrosis factor - α （ TNF -α）
