摘要
目的:观察应用神经节苷脂治疗新生儿缺氧缺血性脑病的疗效。方法:将52例缺氧缺血性脑病患儿随机分为观察组和对照组各26例,两组患儿均采用常规治疗方法,观察组在此基础上给予神经节苷脂治疗,连用10天为1个疗程。观察两组患儿临床症状、体征恢复情况及治疗前、治疗1个疗程、2个疗程后和生后28天NBNA评分情况。结果:观察组和对照组总有效率分别为92.30%和69.23%,差异有统计学意义(P<0.05);两组患儿治疗1个疗程后NBNA评分、治疗2个疗程后NBNA评分和生后28天NBNA评分比较差异均有统计学意义(P<0.05)。结论:神经节苷脂能显著促进新生儿缺氧缺血性脑病临床恢复,无明显不良反应,可有效地控制因缺氧缺血所致的脑水肿,控制脑损伤进一步加重,能改善临床症状。
Objective： To observe the curative effect of ganglioside in treatment of neonatal hypoxic - ischemic encephalopathy （HIE） . Methods： Fifty- two neonates with HIE were randomly divided into observation group and control group, 26 neonates in each group ; the neonates in the two groups were treated with conventional therapy, the neonates in observation group were treated with ganglioside based on conventional therapy, ten days were designed as one course of treatment; the recovery conditions of clinical symptoms and signs, the NBNA scores before treatment, at one course of treatment, two courses of treatment, and at 28 days after birth in the two groups were ob- served. Results： The total effective rates in observation group and control group were 92. 30% and 69. 23%, respectively, there was statis- tically significant difference between the two groups （ P 〈 0. 05） ; there were statistically significant differences in NBNA scores at one course of treatment, two courses of treatment, and at 28 days after birth between two groups （P 〈 0. 05） . Conclusion： Ganglioside can signifi- cantly promote clinical recovery of neonates with HIE, no obvious adverse reactions occur, which can effectively control cerebral edema in- duced by cerebral hypoxia and ischemia, control further aggravation of brain injury, and improve clinical symptoms.
出处
《中国妇幼保健》
CAS
北大核心
2013年第33期5478-5480,共3页
Maternal and Child Health Care of China
关键词
神经节苷脂
缺氧缺血性脑病
新生儿
Ganglioside
Hypoxic - ischemic encephalopathy
Neonate
