期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

孕妇血清缺氧诱导因子1α水平与子痫前期病理特点的关系 被引量：7

暂未订购
导出
摘要 目的探讨孕妇血清缺氧诱导因子1α(HIF-1α)与子痫前期病理特点的关系。方法选取96例子痫前期孕妇为研究对象,其中轻度子痫前期39例,重度子痫前期57例;早发型子痫前期(发病<34孕周)25例,晚发型子痫前期71例;并发胎儿生长受限(FGR)22例。以同期正常妊娠孕妇49例为对照组。采用ELSIA法检测各孕妇血清中可溶性HIF-1α水平。结果轻、重度子痫前期孕妇血清HIF-1α水平均高于对照组(P<0.01);轻度子痫前期与重度子痫前期血清HIF-1α水平比较及早发型子痫前期与晚发型子痫前期血清HIF-1α水平比较,均统计学无差异(P>0.05);并发FGR孕妇的HIF-1α水平高于未并发者(P<0.01)。结论子痫前期孕妇血清HIF-1α水平升高。HIF-1α水平升高与子痫前期及胎儿生长受限的发生有关,与疾病的严重程度、发病时间无关。
作者 鲁晓燕 刘曼华 赵枰 郑艳莉
机构地区 南通市第一人民医院
出处 《山东医药》 CAS 2013年第38期64-65,共2页 Shandong Medical Journal
关键词 子痫前期 缺氧诱导因子1Α 孕妇
分类号 R714.24 [医药卫生—妇产科学]
  • 相关文献

参考文献14

  • 1段涛.子痫前期-子痫相关问题近十年的回顾与展望[J].中华妇产科杂志,2013,48(4):268-271. 被引量：22
  • 2孙曙光,沈娜,郑艳辉,尚涛.缺氧诱导因子1α及其靶基因在子痫前期患者胎盘组织中的表达[J].中华妇产科杂志,2006,41(7):440-444. 被引量：11
  • 3谢娅,杨玲竹.缺氧诱导因子-1在妊娠期高血压疾病中的研究进展[J].国外医学（妇产科学分册）,2006,33(6):382-385. 被引量：3
  • 4Sakamoto T, Seiki M. Mint3 enhances the activity of hypoxia-in- ducible factor-1 in macrophages by suppressing the activity of factor inhibiting HIF-1 [J]. Biol Chem, 2009,284(1) :30350-30359.
  • 5Yamamoto Y, Ibusuki M, Okumura Y, et al. Hypoxia-inducible factor lalpha is closely linked to an aggressive phenotype in breast- cancer [ J ]. Breast cancer Res Treat, 2008,110 ( 3 ) :465 475.
  • 6Cameron CM, Harding F, Hu WS, et al. Activation of hypoxic re- sponse in human embryonicstem cell-derived embryoid bodies[J]. Exp Bio Med, 2008,233(8) :1044-1057.
  • 7金丽,陈芹,李方英,鲁晨,张文敏,班开斌.妊高征孕妇胎盘组织中IGF-1、HIF-1α的表达变化及意义[J].山东医药,2009,49(6):7-9. 被引量：5
  • 8Hayashi M, Sakata M, Takeda T, et al. Induction of glucose trans- porter 1 expression through hypoxia-inducible factor l alpha under hypoxic conditions in trophoblast-derived ceils [ J ]. J Endocrinol, 2004,183( 1 ) :145-154.
  • 9Cowden Dahl KD, Fryer BH, Mack FA, et al. Hypoxia-indueible factors lalpha and 2alpha regulate trophoblast differentiation [J]. Mol Cell Biol, 2005,25(23) :10479-10491.
  • 10De Marco CS, Caniqqia I. Mechanisms of oxygen sensing in human trophoblast cells [ J ]. Placenta, 2002,23 ( Suppl A) : $58 -$68.

二级参考文献56

  • 1尚丽新,王晶,张丽江,高红,曲冬颖,王继红.胰岛素样生长因子1及胰岛素样生长因子结合蛋白1表达与妊娠期高血压疾病发病的关系[J].中华妇产科杂志,2005,40(8):516-520. 被引量：2
  • 2杨孜,林其德.子痫前期-子痫的病理生理学研究[J].中华妇产科杂志,2006,41(8):507-508. 被引量：28
  • 3Levine RJ, Lam C, Qian C, et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med, 2006,355 : 992-1005.
  • 4Fonsatti E, Sigalotti L, Arslan P, et al. Emerging role of endoglin (CD105) as a marker of angiogenesis with clinical potential in human malignancies. Curr Cancer Drug Targets, 2003, 3:427- 432.
  • 5Venkatesha S, Toporsian M, Lam C, et al. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med, 2006, 12:642-649.
  • 6Staff AC, Braekke K, Johnsen GM, et al. Circulating concentrations of soluble endoglin ( CD105 ) in fetal and maternal serum and in amniotic fluid in preeclampsia. Am J Obstet Gynecol,2007,197 : 176.
  • 7Salahuddin S, Lee Y, Vadnais M, et al. Diagnostic utility of soluble fms-like tyrosine kinase 1 and soluble endoglin in hypertensive diseases of pregnancy. Am J Obstect Gynecol, 2007, 197:28.
  • 8Robinson C J, Johnson DD. Soluble endoglin as a second-trimester marker for preeclampsia. Am J Obstet Gynecol, 2007,197 : 174.
  • 9Roberts JM, Lain KY. Recent insight into the pathogenesis of preeclampsia placenta[J]. 2002,23 (5) :359-372.
  • 10Buekway CK,Guevara-Aguirre J,Pratt KL,et al. The IGF-I generation test revisted : a maker of GH ensitivity [ J ]. J Clin Endocrinol Metab,2001,86( 11 ) :5176-5183.

共引文献48

同被引文献60

  • 1戎祯祥,剧永乐,陈小伍,伍锦浩,朱达坚.穿孔性阑尾炎行腹腔镜与开腹手术的疗效对比分析[J].中国实用外科杂志,2004,24(9):560-561. 被引量：100
  • 2林其德,段涛,孔北华,林建华,滕银成,古航,孙丽洲,李笑天,贺晶,李力,刘兴会,潘琢如,苟文丽,马玉燕,牟瑞丽.子痫前期-子痫相关问题的讨论[J].现代妇产科进展,2006,15(9):641-653. 被引量：20
  • 3谢幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2013:169.
  • 4吕艳关,臧晓娟,范广来,等.胎盘组织缺氧诱导因子-1α的表达和血管内皮生长因子及其受体-1水平在子痫前期的作用研究[J/CD].中华临床医师杂志:电子版,2013,8(11):4825-4829.
  • 5王青云.穿孔性阑尾炎行腹腔镜与开腹手术的疗效对比分析[J].医学信息,2013(23):82.
  • 6Emanuel M,Butt S. Frequency and factors leading to re- current pre-eclampsia[J]. J Pak Med Assoc, 2015, 65 (11) : 1173-1177.
  • 7解长银,臧晓娟,魏红,等.子痫前期患者胎盘组织及血浆中TGF-β1的表达及临床意义[J].中华临床医师杂志,2013,7(24):11427-11431.
  • 8Deepthi G, Chaithri PK, Latha P, et al. TGFB1 functional gene polymorphisms(C-509T and T869C) in the maternal susceptibility to pre-eclampsia in South Indian women[J]. Scand J Immunol, 2015,82 (4) : 390-397.
  • 9Maebayashi Asanuma A, Yamamoto T, Azuma H, et al. Expression of placenta growth factor, soluble fms-like tyrosine kinase-1, metal-responsive transcription factor- 1, heme oxygenase 1 and hypoxia inducible factor-la mR- NAs in pre-eclampsia placenta and the effect of pre-ec- lampsia sera on their expression of choriocarcinoma ceils [J]. J Obstet Gynaeeol Res, 2014,40 (10) : 2095-2103.
  • 10Palmer KR,Kaitu Lino TJ, Hastie R, et al. Placental-spe- cific sFLT-1 elSa protein is increased in preeclampsia,an- tagonizes vascular endothelial growth factor signaling, and has antiangiogenic activity [J]. Hypertension, 2015, 66 (6) : 1251-1259.

引证文献7

二级引证文献47

山东医药
2013年 第38期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部