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代谢组学在多囊卵巢综合征研究中的应用 被引量：3

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摘要 多囊卵巢综合征（PCOS）是育龄期妇女常见的一种复杂的内分泌及代谢紊乱疾病,具有高度异质性的特点.主要临床表现为月经失调、不孕、多毛和痤疮,并伴有排卵功能紊乱和高雄激素血症,发病率为4％～12％,是引起不排卵性不孕的主要原因.目前其发病机制尚不明确.作为系统生物学研究的关键技术和方法,代谢组学是继基因组学和蛋白质组学之后新近发展起来的一门学科,其通过系统研究代谢产物的变化规律,跳过体内复杂的调控过程揭示生命活动的代谢本质.代谢组学技术自提出后主要用于临床诊断疾病和药物的药理毒理研究.
作者 李修阳 张宁 任健 徐琬梨 李毓秋 刘家义
机构地区 山东中医药大学
出处 《山东医药》 CAS 2013年第34期95-97,共3页 Shandong Medical Journal
基金 国家自然科学基金资助项目(81273667)
关键词 多囊卵巢综合征 代谢组学
分类号 R271.1 [医药卫生—中医妇科学]
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参考文献16

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二级参考文献27

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共引文献62

同被引文献20

  • 1余亚信,李学军,闫冰,王丽英,张惠杰,杨叔禹.胰岛素增敏剂治疗多囊卵巢综合征疗效的系统评价[J].中华临床医师杂志（电子版）,2011,5(22):6671-6679. 被引量：16
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  • 10魏巍,孙壮状,安媛,李力男,关咏梅,王卓然.达英-35与胰岛素增敏剂治疗多囊卵巢综合征后促排卵药物的效果观察[J].实用妇产科杂志,2009,25(10):618-621. 被引量：36

二级引证文献11

山东医药
2013年 第34期

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