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Ⅰ型组蛋白去乙酰化酶在心肌肥厚中的靶点作用 被引量：1

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摘要 组蛋白去乙酰化酶是一种转录后修饰的酶类,可以使组蛋白去乙酰化。Ⅰ型组蛋白去乙酰化酶可促进心肌肥厚发生。在Ⅰ型组蛋白去乙酰化酶中,组蛋白去乙酰化酶2(HDAC2)由肥大刺激和热休克蛋白70诱导活化。活化的HDAC2通过抑制级联信号Krüppel样因子4(KLF4)或肌醇多磷酸磷酸酶-5-f(Inpp5f)触发肥大。因此,调节HDAC2的酶类,例如选择性组蛋白去乙酰化酶抑制剂,被认为是治疗心脏疾病尤其是阻止心肌肥厚的一个重要靶标。该文讨论Ⅰ型组蛋白去乙酰化酶在调节心肌肥厚中所起的关键作用。
作者 曹珊珊 苏永立 李瑞芳 王建刚 方伟进 岳阳阳
机构地区 洛阳东方医院药剂科 河南科技大学医学院药理学和分子生物学实验室
出处 《国际心血管病杂志》 2013年第6期359-361,共3页 International Journal of Cardiovascular Disease
关键词 Ⅰ型组蛋白去乙酰化酶 组蛋白去乙酰化酶抑制剂 心肌肥厚 分子靶点
分类号 R542.2 [医药卫生—心血管疾病]
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参考文献25

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同被引文献27

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国际心血管病杂志
2013年 第6期

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