摘要
目的探讨癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)联合检测在肺癌诊断中的临床价值。方法采用化学发光法对61例肺癌患者和38例肺部良性病变患者血清CEA、CYFRA21-1、NSE水平进行检测。根据接受者工作特性曲线(ROC),确定最佳截断点及诊断灵敏度、特异度。结果肺癌组患者血清CEA、CYFRA21-1、NSE水平均明显高于肺部良性病变组,差异有统计学意义(P<0.05);3项肿瘤标志物在不同病理类型肺癌中的水平差异无统计学意义(P>0.05);CEA诊断肺癌最佳截断点为3.50ng/mL,灵敏度和特异度分别为52.5%、94.7%;CYFRA21-1最佳截断点为5.21ng/mL,灵敏度和特异度分别为67.2%、93.1%;NSE最佳截断点为18.09ng/mL,灵敏度和特异度分别为77.0%、52.6%。3项指标联合检测的灵敏度为96.7%,高于3项单独检测时的灵敏度(P<0.05)。结论检测CEA、CYFRA21-1和NSE对肺癌的诊断有一定价值,3者联合检测有明显的互补性,可提高肺癌诊断的灵敏度。
Objective To study the clinical significance of Carcinoembryonic antigen （CEA） and cytokeratin 19 fragment （CY- FRA21-1） ,neuron specific enolization enzyme （NSE） combined detection in the diagnosis of lung cancer. Methods Using the Chemiluminescence to detect the level of CEA,NSE and CYFRA21-1 in 61 patient with lung cancer（lung cancer group） and 38 pa- tients with benign diseases（control group）. All datas were analyzed with t test. Optimal cut-off point and diagnostic sensitivity, spe- cificity were obtained by receiver operating characteristic curve（ROC）. Results The level of serum CEA,NSE and CYFRA21-1 in Lung cancer group was significantly higher than that in control group（P〈0.05）. The expression level of three tumor markers was no statistically significant difference in the different pathological types of lung cancer（P〉0.05）. The cut-off point of CEA was 3.50 ng/mL, sensitivity and speciality were 52.5 %, 94.7 % respectively. The cut-off point of CYFRA21-1 was 5.21 ng/mL, the sensitiv- ity and specificity were 67.2% ,93.1%. The cut-off of point NSE was 18.09 ng/mL, the sensitivity and specificity were 77.0%, 52.60//00. The three combined detection sensitivity was 96.7%, significantly higher than separate one（P〈0.05）. Conclusion The three tumor markers（CEA,CYFRA21-1 ,NSE） might be valuable in the diagnosis of lung cancer. The combined detection could be used as a better pattern for screening lung cancer.
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第31期3764-3765,共2页
Chongqing medicine
