摘要
目的探讨降钙素原(PCT)在卒中相关性肺炎(SAP)的诊断、治疗及预后判断过程中的作用。方法检测27例SAP患者、31例卒中对照者的血清中PCT、高敏C反应蛋白(hs-CRP)浓度,计算临床肺部感染评分(CPIS),并进行统计学分析。结果 SAP组患者的CPSI、hs-CRP、血清PCT浓度明显高于卒中组(P<0.01),在治疗好转后均明显下降。在SAP患者中,死亡组患者的PCT浓度明显高于存活组(P<0.01)。相关分析显示,血清PCT浓度与CPSI呈正相关。ROC曲线分析结果显示,血清PCT诊断SAP的临界值为0.9ng/mL,其灵敏度及特异度分别为88.6%和79.3%,明显优于hs-CRP的诊断价值。结论 SAP患者的血清PCT明显升高,且与患者的预后相关,对SAP诊断的价值明显高于hs-CRP。PCT可以作为SAP患者诊断、病情和预后评估的较好临床指标之一。
Objective To observe the value of procalcitonin（PCT） in the diagnosis,treatment and prognosis judgement of stoke- associated pneumonia（SAP）. Methods The serum procalcitonin, hs-CRP and clinical pulmonary infection scores （CPSI） of two groups were detected：SAP group（including 27 patients of stoke-associated pneumonia） and control group（including 31 healthy ob- jects）. Results The CPSI,hs-CRP and serum concentration of PCT in SAP group were significantly higher than control group（P〈 0.01）, and decreased significantly when get better after treatment. The serum concentration of PCT in SAP group was significantly higher than control group（P〈0.01）. In SAP group,the serum concentration of PTC was positively associated with CPSI scorers. Moreover, the results of ROC analysis showed that the cut off of serum procalcitonin for the diagnosis of SAP was 0.9 ng/mL. The sensitivety was 88.6 % and the specifity was 79.3 % ,which was superior to hs-CRP. Conclusion The serum concentration of PCT in SAP patients is higher and it is associated with the prognosis. It might be a better clinical marker for the diagnosis and prognosis of SAP.
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第31期3738-3739,3743,共3页
Chongqing medicine
基金
国家自然科学基金资助项目(81000765)
关键词
诊断
预后
卒中相关性肺炎
降钙素原
diagnosis
prognosis
stoke-associated pneumonia
procalcitonin
