摘要
目的探讨白细胞介素(IL)-1β+3953位点基因多态性与肺结核疾病易感性的关系。方法计算机检索数据库,收集有关IL-1β+3953位点基因多态性与肺结核疾病易感性关系的病例对照研究,提取纳入文献的相关数据进行Meta分析,以病例组和对照组IL-1β+3953位点各种基因模型的比值比(OR)为效应指标,漏斗图检测发表偏倚。结果共8篇研究符合纳入标准,累计病例数1 160例,对照组1 216例。Meta分析表明IL-1β+3953位点基因多态性与肺结核疾病易感性无明显关联性。结论 IL-1β+3953位点基因多态性与肺结核疾病易感性无明显关联性。
Objective To explore the association between the IL-1βgene ＋3953 polymorphism and tubercu-losis susceptibility .Methods Data bases were comprehensively searched to retrace all the related studies on the associations between IL-1β gene ＋ 3953 polymorphism and tuberculosis susceptibility . The pooled odds ratios （ OR ） with 95% confidence intervals （95% CI ） of the association between IL-1βgene ＋3953 polymorphism and tuberculosis susceptibility were performed in different genetic model comparison .Publication bias was detected by symmetry of funnel plot .Results Eight original studies with a total of 2 376 subjects （1 160 patients and 1 216 controls ） were chosen for the final data combination .The results of meta-analysis showed that there are no signifi-cant associations between IL-1βgene＋3953 polymorphism and tuberculosis susceptibility in different genetic mod-el comparison .Conclusion Meta-analysis strongly suggests that there are no significant associations between IL-1βgene＋3953 polymorphism and tuberculosis susceptibility .
出处
《山西医药杂志（上半月）》
CAS
2013年第11期1233-1235,共3页
Shanxi Medical Journal
关键词
白细胞介素1
多态性
单核苷酸
结核
肺
易感性
META分析
Interleukin-1
Polymorphism, single nucleotide
Tuberculosis, pulmonary
Susceptibility
Meta-analysis
