摘要
目的分析金黄色葡萄球菌(SAU)菌血症的临床特点和耐药性,为临床治疗提供依据。方法对医院2001年1月-2011年12月53例血培养证实为SAU感染的病例进行回顾性分析。结果患者以皮肤科、ICU及血液科为主,73.6%的患者有高热的表现;53例患者中耐甲氧西林金黄色葡萄球菌(MRSA)感染23例,占43.4%;甲氧西林敏感金黄色葡萄球菌(MSSA)感染30例,占56.6%;MRSA组和MSSA组在进行侵入性医疗操作次数上差异有统计学意义(P<0.01);MRSA组未愈和死亡病例12例,占52.2%,MSSA组为3例,占10.0%,差异有统计学意义(P<0.01);MRSA对替考拉宁、利奈唑胺和万古霉素100.0%敏感,对喹奴普汀/达福普汀及利福平耐药率为5.3%和26.1%,对其他抗菌药物耐药率均较高;MSSA对青霉素耐药率为96.6%,对其他抗菌药物较敏感。结论 SAU菌血症预后差,病死率高,一旦怀疑血液感染应尽早做血培养和药敏试验,选择敏感的抗菌药物。
OBJECTIVE To analyze the clinical characteristics of bacteremia caused by Staphylococcus aureus and analyze the drug resistance so as to guide the clinical treatment. METHODS Totally 53 cases of patients with confirmed S. aureus infections, who were treated in the hospital from Jan 2001 to Dec 2011, were retrospectively analyzed. RESULTS Most of the cases of S. aureus infections were from the dermatology department, ICU, and hematology department% 73.6% of the cases presented the clinical manifestations of fever. Of the 53 cases of patients, there were 23 （43.4%） cases of methicillin-resistant S. aureus （MRSA） infections and 30 （56.6%） cases of methicillin-sensitive S. aureus （MSSA） infections. There was a significant difference in the frequency of invasive operation between the MRSA group and the MSSA group（P〈0.01）. Totally 12 （52.2 %） cases died in the MRSA group, and 3 （10.0%） cases died in the MSSA group, the difference was significant（P〈0.01）. The MRSA strains were 100. 0% susceptible to teicoplanin, linezolid, and vancomycin, the drug resistance rates to quinupristin-dalfopristin and rifampicin were 5.3% and 26.1%, respectively, and the strains were highly resistant to other antibiotics% the drug resistance rate of the MSSA strains to penicillin was 96.6%, and the strains were susceptible to other antibiotics. CONCLUSION The patients with S. aureus bacteremia have the poor prognosis with high mortality, once the bloodstream infections are suspected to occur, it is necessary to perform the blood culture and drug susceptibility testing as early as possible so as to choose sensitive antibiotics.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第22期5569-5571,共3页
Chinese Journal of Nosocomiology
基金
广东省科技社会发展基金项目(2012B031800042)
关键词
金黄色葡萄球菌
菌血症
耐药性
Staphylococcus aureus
Bacteremia
Drug resistance
