摘要
评价我国1999年～2012年药物性肝损伤（DILI）病因变化特点。在Medline、EMBASE、Wanfang、VIP和CNKI中国期刊全文数据库中检索已发表的关于DILI的病例序列研究。利用R软件对各药物所占比率进行单个率的Meta分析。Meta分析表明：抗结核药是1999年～2005年DILI的首要病因，其构成比为26．54％。2006年～2012年DILI的病因则以中药为主，其构成比为30．38％，而抗结核药所占比例下降（构成比为20．57％），抗肿瘤化疗药所占比例（构成比为10．26％）较1999年～2005年（构成比为8．73％）增加。我国DILI病因存在时间演变，中药及抗肿瘤化疗药所占比例上升，抗结核药所占比例有所下降，但仍是DILI主要病因之一．
To evaluate the chronological evolvement of the etiology of drug-induced liver injury （DILI） in China during the period from 1999 to 2012. Correlated DILI case series studies were searched in Medline, EMBASE, Wanfang, VIP and National Knowledge Infrastructure. R software was used for meta analysis of constituent ratios of each drug. Tuberculostatics （constituent ratio=26.54%） were the leading cause of DILl in China from 1999 to 2005. However, herbal medicine （constituent ratio=30.38%） became the leading cause of DILI in China from 2006 to 2012. In the period from 2006 to 2012, the constituent ratio （20.570%） of tuberculostatics decreased as compared with that in the period from 1999 to 2005. Additionally, the constituent ratio of antineoplastic drug-increased during the period from 2006 to 2012 （constituent ratio =10.26%） as compared with that in the period from 1999 to 2005 （constituent ratio=8.73%）. In conclusion, the profile of DILI causes changes chronologically. Herbal medicine replacing tuberculostatics has become the leading cause of DILI. The constituent ratio of antineoplastic drug also increases chronologically.
出处
《医学与哲学（B）》
2013年第10期9-13,共5页
Medicine & Philosophy(B)
关键词
药物性肝损伤
META分析
病因
drug- induced liver disease, Meta- analysis, etiology
