摘要
3 (β 羟乙基砜基 )苯胺在催化剂镍的存在下与醛发生加氢反应 ,可直接制得 3 (β 羟乙基砜基 )N 乙基苯胺。运用高效液相色谱 /质谱联机系统对反应生成的中间产物进行分析 。
Hydrogenating 3 ( β hydroxy ethyl sulfonyl) aniline and acetaldehyde in the presence of Raney Nickel as a catalyst, 3 ( β hydroxy ethyl sulfonyl) N ethyl aniline was obtained with 98% conversion and 95% mono alkylation selectivity under optimum conditions By using high performance liquid chromatography/mass selective detection technique to characterize the structures of the products, the mechanism of reductive alkylation is proposed From the intermediates determined, it is shown that the reaction mechanism would go via an unstable N α hydroxy ethylaniline derivative and Schiff base stage. After hydrogenation of Schiff base, finally the product 3 ( β hydroxy ethyl sulfonyl) N ethyl aniline was formed
出处
《色谱》
CAS
CSCD
北大核心
2000年第6期532-535,共4页
Chinese Journal of Chromatography
基金
东港染料科研基金资助
关键词
LC/MS
反应历程
3-(β-羟乙基砜基)N-乙基苯胺
high performance liquid chromatography/mass selective detection
reductive alkylation
reaction mechanism
3 ( β hydroxy ethyl sulfonyl) aniline
3 ( β hydroxy ethyl sulfonyl) N ethyl anilinP
