摘要
Egg white protein bonded columns were developed for HPLC. These columns can be used under aqueous mobile phase and separate various kinds of drug enantiomers. Hyphenated techniques using protein bonded columns with LC/MS and/or column switching have been recognized as integral methods in pharmaceutical research to analyze drug enantiomers. Therefore, these methods are very useful for research fields of pharmacokinetics and pharmacology.
Egg white protein bonded columns were developed for HPLC. These columns can be used under aqueous mobile phase and separate various kinds of drug enantiomers. Hyphenated techniques using protein bonded columns with LC/MS and/or column switching have been recognized as integral methods in pharmaceutical research to analyze drug enantiomers. Therefore, these methods are very useful for research fields of pharmacokinetics and pharmacology.
出处
《色谱》
CAS
CSCD
北大核心
2000年第6期508-517,共10页
Chinese Journal of Chromatography
基金
ThisworkwassupportedbyEisaiCo .Ltd .
关键词
蛋清蛋白质键合柱
HPLC
LC/MS
chiral separation
LC/MS
protein column
plasma direct injection
column switching
