摘要
为探讨血清肿瘤坏死因子 ( TNF- α)和一氧化氮 ( NO)在 型糖尿病 ( NIDDM)及其并发症中的变化 ,分别采用 ELISA法和 Griess法对 76例 NIDDM患者血清 TNF-α及 NO含量进行了检测 ,并与 38例正常人进行比较。结果表明 NIDDM患者血清 TNF- α和 NO代谢产物亚硝酸盐 ( NO2 )含量显著高于正常对照组 ( P<0 .0 1 ) ;有并发症组升高更为显著 ( P<0 .0 1 ) ;血清 TNF-α和 NO水平与空腹血糖 ( FPG)不相关 ;TNF- α与病程、脂蛋白 ( a) [LP( a) ]、甘油三酯 ( TG)、低密度脂蛋白 ( L DL)呈正相关 ;NO与病程不相关 ,与 L P( a)、TG、LDL呈正相关 ;TNF- α和 NO之间亦具有显著的相关性。结果提示 TNF- α和 NO共同参与糖尿病及其并发症的发生发展 ,动态检测血清 TNF-α和 NO含量可作为临床观察
The serum levels of tumor necrosis factor α(TNF α)and nitric oxide (NO) were determined with ELISA and Gress in 76 cases of NIDDM,38 normal subjets.The results were:were the serum TNF α and NO levels in NIDDM were significantly higher than that in of normal controls ( P <0 01).The serum levels of TNF α and NO havn't associated with blood glucose TNF α has correlated with the course of disease,LP (a),LDL and TG.NO hasn't associated with course of disease but has correlated with LP(a),LDL and TG. TNF α also has correlated with its complications The detection of TNF α and NO might be significant observing factors of clinical changes of NIDDM.
出处
《陕西医学检验》
2000年第4期53-55,共3页
Shaanxi Journal of Medical Laboratory Sciences
关键词
Ⅱ型糖尿病
肿瘤坏死因子
一氧化氮
并发症
Non insulin dependent diabetes mellituras Nitric oxide Tumor necrosis factor Complication
